Survival Probability in Multidrug Resistant Pulmonary Tuberculosis Patients in a South Indian Region.

Drug-resistant tuberculosis is a burgeoning threat to public health requiring novel strategies to combat the infection. Although national tuberculosis elimination programs focus on improving health services, challenges in eradicating tuberculosis still exist. Factors attributing to unfavorable outcomes are unknown in Warangal district of Telangana state.

Development of risk prediction scores for diabetic peripheral neuropathy patients.

Objectives: Risk prediction scores are important for early diagnosis and treatment of diseases. Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes, but the early diagnosis is challenging. This study developed a risk prediction model for DPN based on modifiable risk factors.

Bio nanocomposites of graphene oxide with carboxymethyl guargum: fabrication and characterization and application for type 1 diabetes.

Islet cells transplantation has limitations like low survivability, which can be overcome by using extracellular matrix mimicking three-dimensional (3D) scaffolds, which supports the growth and proliferation of seeded cells. This study was aimed to investigate the role of novel 3D carboxymethyl guargum (CMGG) nanocomposite with reduced graphene oxide (rGO) for proliferation of pancreatic islet cells (RIN-5F) and rate of insulin secretion of RIN-5F cells. Scanning electron microscope and Fourier transform infrared results have demonstrated good porosity and the chemical interactions between CMGG and rGO.

Nanofibrous scaffolds of carboxymethyl guargum potentiated with reduced graphene oxide for in vitro and in vivo wound healing applications.

Nanofiber scaffolds mimic the extracellular matrix (ECM) and help in fibroblasts proliferation which is the main constituent for wound healing. This study aims to evaluate the wound healing potential of electrospun nanofibers fabricated by carboxymethyl guargum (CMGG), reduced graphene oxide (rGO) and polyvinyl alcohol. The nanofibers have shown desired properties like excellent porosity and good water holding capacities.

Bioengineering for curcumin loaded carboxymethyl guargum/reduced graphene oxide nanocomposites for chronic wound healing applications.

Biomimetic scaffolds engineering for improved collagen, epithelial cutaneous and fibrous tissue regeneration remains challenging for wound healing. To address these issues, this study aimed to report on the fabrication and characterization of electrospun of carboxymethyl guargum (CMGG), reduced graphene oxide (rGO) nanocomposite dressings loaded with curcumin for chronic wound healing applications. SEM and XRD examined the morphology of nanofibers and resulted in excellent porosity.

Role of diet and lifestyle modification in the management of nonalcoholic fatty liver disease and type 2 diabetes.

Nonalcoholic fatty liver disease (NAFLD) is considered as the hepatic evidence of insulin resistance which is the hallmark of type 2 diabetes. NAFLD is considered as the risk factor for developing type 2 diabetes and has a high frequency of occurrence in those with existing type 2 diabetes. Compared with patients with only NAFLD or type 2 diabetes, these patients show a poor metabolic profile and increase mortality.

Role of hypothyroidism and associated pathways in pregnancy and infertility: Clinical insights.

Thyroid disorders are the most common endocrine problems in women. In most of the cases, thyroid can lead to infertility or miscarriages. The etiology of infertility is multifactorial with thyroid disorders as the most common presenting factor, hypothyroidism in particular.

Fabrication and characterization of carboxymethyl guar gum nanocomposite for application of wound healing.

Bio scaffolds used for cutaneous tissue regeneration is a challenging issue in the healthcare system. To help this problem, we aimed to report on fabrication and characterization of citric acid cross-linked carboxymethyl guar gum (CMGG) nanocomposite films loaded with ciprofloxacin for faster wound healing application. Differential scanning calorimeter (DSC) and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy studies, dynamic light scattering (DLS), scanning electron microscopy (SEM) and X-ray diffraction (XRD) were used as analytical techniques for characterization of the nanocomposite film.

Cerebroprotective effect of resveratrol through antioxidant and anti-inflammatory effects in diabetic rats.

Oxidative stress and inflammation have been implicated in cerebral ischemia/reperfusion injury and complication of diabetes. The present study was designed to evaluate whether resveratrol has cerebroprotective action through antioxidant and anti-inflammatory actions in diabetic rats. Bilateral common carotid artery occlusion (30 min) and reperfusion (4 h) was employed to induce cerebral infarction in diabetic Wistar rats.

Cerebroprotective potential of resveratrol through anti-oxidant and anti-inflammatory mechanisms in rats.

Oxidative stress and inflammation are two important pathological mechanisms involved in cerebral ischemia and reperfusion injury. In pathological conditions such as cerebral infarction, the free radical production is greater than that of elimination by endogenous anti-oxidant system, by this undesirable effect brain is highly injured. Resveratrol is reported to have anti-oxidant and anti-inflammatory, athero-protective activities.