Acremine G, dimeric metabolite from cultures of Acremonium byssoides A20.

A new dimeric fungal metabolite, racemic acremine G, was isolated from cultures of the fungus Acremonium byssoides A20, along with the known acremines A-F. Its structure was elucidated by NMR spectroscopy and X-ray crystallography. A possible biosynthetic pathway is discussed.

Absolute configuration of sporotricale and structure of 6-hydroxysporotricale.

The absolute configuration of the two stereocenters of (+)-sporotricale (2a), a bioactive phthalide secondary metabolite, was determined through circular dichroism and by applying Mosher's method. The structure of 6-hydroxysporotricale (2c), isolated from cultures in vitro of Sporotrichum laxum, was also elucidated.