Publications by authors named "Orr Shormoni"
RNA editing alterations define manifestation of prion diseases.
Proc Natl Acad Sci U S A
September 2019
Article Synopsis
- - Prion diseases are deadly neurodegenerative disorders caused by the abnormal folding of prion proteins, with sporadic Creutzfeldt-Jakob disease (sCJD) being the most common, leading to rapid dementia in patients.
- - The study utilized a mouse model (tg340-129MM) that mimics sCJD to investigate molecular changes during disease progression, focusing on transcriptome alterations in the brain.
- - Findings revealed specific changes in RNA editing pathways linked to stress and lysosome function, suggesting these changes might be protective during different disease stages and highlighting potential mechanisms involved in the disease's progression.