Publications by authors named "Ornella Rizzo"
Article Synopsis
- Primary bone lymphoma of the spine (PBL) is a rare condition that can be misdiagnosed due to its similarities with infections and other diseases.
- The case involves a woman in her sixties with chronic low back pain and cruralgia, leading to various imaging tests that suggested spondylodiscitis but ultimately identified aggressive diffuse large B-cell lymphoma.
- This case emphasizes the challenges in diagnosing PBL, as both PBL and infections display similar symptoms and imaging characteristics, making accurate differentiation essential for proper treatment.
Over the past three decades, the treatment of lymphoproliferative disorders has undergone profound changes, notably due to the increasing availability of innovative therapies with the potential to redefine clinical management paradigms. A major impact is related to the development of monoclonal antibodies, checkpoint inhibitors, bispecific antibodies, and chimeric antigen receptor T (CAR-T) cell therapies. This review discusses the current landscape of clinical trials targeting various hematological malignancies, highlighting promising early-phase results and strategies to overcome resistance.
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