Publications by authors named "Ornella Conort"
The French Health Authority recently published guidelines about patient self-administration of medications for voluntary hospitalized patients under medical supervision. This study aimed to assess medication management practices in our hospital and provide recommendations for self-administration medication. A prospective monocentric study was performed from January to June 2023, involving patient and nurse surveys based on the guidelines from the French Health Authority.
View Article and Find Full Text PDFPrescribing errors related to computerized physician order entry are current and may have serious consequences for patients. They can be detected by pharmacists during prescriptions analysis and lead to pharmacist's interventions. In France, few monocentric studies have studied Pharmacist Interventions triggered by prescribing errors identified as System-Related Errors (PISREs) in French hospitals.
View Article and Find Full Text PDFObjective: To study in daily practice the risk of immunogenicity of patients treated with the biosimilar rituximab (RTX) GP2013 used for chronic inflammatory rheumatic disorders.
Methods: A prospective monocentric routine care study was carried out between September 2018 and May 2021, including consecutive patients treated with the biosimilar RTX GP2013. Biosamples were taken before each infusion to quantify anti-RTX antibodies (ADAbs) and serum RTX trough levels by ELISA (Lisa Tracker Duo Rituximab, LTR005, Theradiag).
Article Synopsis
- The study aimed to assess how a clinical pharmacist's consultation affects the decision of patients with inflammatory rheumatic diseases to switch to biosimilars compared to those who did not receive this consultation.
- It involved analyzing 141 adult patients, revealing that those who had a consultation were more likely to switch to biosimilars (69.4% vs 41.1%).
- Although there was a good initial switch rate, retention of patients on biosimilars after one year was slightly lower in the intervention group (72.5% vs 81.3%), indicating the need for further research on the long-term effects of pharmacist consultations.
Objectives: Computerised physician order entry (CPOE) systems facilitate the review of medication orders by pharmacists. Reports have emerged that show conception flaws or the misuse of CPOE systems generate prescribing errors. We aimed to characterise pharmacist interventions (PIs) triggered by prescribing errors identified as system-related errors (PISREs) in French hospitals.
View Article and Find Full Text PDFObjectives: Clinical pharmacists' interventions (PIs) are an important element in ensuring good pharmaceutical care. We aimed to develop and validate a comprehensive multidimensional tool for assessing the potential impact of PIs for daily practice of medication review.
Methods: Experts of the French Society of Clinical Pharmacy (SFPC) developed the CLinical, Economic and Organisational (CLEO) tool, consisting of three independent dimensions concerning clinical, economic and organisational impact.
Objectives: In spondyloarthritis (SpA), improving patients' knowledge on their biologics is a key factor to enhance adherence. The information given to the patient has to ensure the acquisition of safety skills regarding their treatment. The aims of this trial were to evaluate the impact of a pharmacist's educational interview on knowledge and adherence to biologics in these patients.
View Article and Find Full Text PDFObjective: To evaluatre the risk of immunogenicity in patients with chronic inflammatory diseases who experienced successive non-medical swiches to different biosimilars infliximab.
Patients And Methods: Observational study over a 3-year observation period assessing the risk of immunogenicity in i) patients in maintenance therapy with innovator infliximab who were successively switched to CT-P13, then to SB2 (cohort-1) and ii) biologic-naive patients initiated with CT-P13 before being switched to SB2 (cohort-2). A propotion meta-analysis was also performed, integrating our results to 16 additional studies.
Article Synopsis
- - The study evaluated the effectiveness of switching from innovator infliximab to its biosimilar in adult patients at Cochin University Hospital, measuring retention rates after three infusions and examining associated factors.
- - Out of 260 patients, an 85% retention rate for the biosimilar was noted, but 23% (59 patients) eventually discontinued due to inefficacy, with no serious side effects reported.
- - Overall, objective disease activity measures showed no significant changes post-switch, although some subjective outcomes, particularly in patients with axial spondyloarthritis, indicated a slight increase, suggesting potential attribution effects rather than actual efficacy changes.
Introduction: Assessing the significance of pharmacist interventions (PIs) is essential to demonstrate the added value of pharmacists. Methods and tools for assessing the potential significance of PIs are diverse and their properties are questionable.
Objectives: We aimed to systematically review the tools available to assess the potential significance of PIs.
Background: The development of clinical pharmacy activities in most European countries is underway; however, data on these activities are still poorly reported. Multicenter studies are necessary to standardize and demonstrate the value of clinical pharmacy activities in these countries.
Objective: To document clinical pharmacists' daily routine interventions (PIs) to identify trends of intervention, drugs, and situations most frequently associated with drug-related problems (DRPs) and to estimate physicians' acceptance of PI.
The huge number of drug interactions makes it impossible to memorize them all. Detecting them and preventing adverse effects requires the use of reference works or databases. There are numerous discordances between the so-called "reference" books and databases.
View Article and Find Full Text PDFObjective: To compare and analyze the number and types of pharmacist interventions when prescriptions were handwritten (period 1) or entered on 2 different computerized physician order entry systems (CPOE): Phedra (period 2) and Actipidos (period 3).
Methods: This study took place over 54 weeks (18 weeks for each period) in a 46-bed internal medicine department. Pharmacist interventions were categorized as either simple substitution to an available drug or "complex" interventions such as changing dosage (D), changing drug (M), stopping or substituting in cases of contraindication or overdosing (CO), new medication (N) and identifying errors due to CPOE (C).
Objective: To validate an instrument for documentation of clinical pharmacy interventions in French speaking hospitals in France and outside of France.
Method: A panel of 12 French speaking clinical pharmacists (six from France; six from French speaking countries) was asked to analyse a set of 60 pharmacist's interventions on drug prescription. They used a form including (1) the identification of the drug related problems (DRPs) (10 items), (2) the pharmacist's intervention (7 items).
Study Objectives: To assess the knowledge of prescribers regarding intravenous to oral conversions of fluoroquinolones, the frequency and time until conversion, and to compare prescriber knowledge with the data collected concerning the reasons stated for continuation of intravenous fluoroquinolones.
Design: Prospective chart review and questionnaire.
Setting: Large teaching hospital in Paris, France.