Publications by authors named "Orn-Usa Suwitheechon"

Objective: To develop a technique for isolation and culture of canine insulinoma cells and assess expression of cellular hexokinases (glucokinase and hexokinase I) and expression and secretion of insulin from these cells in vitro.

Sample: Pancreatic insulinomas and normal pancreatic tissue from 4 and 3 dogs, respectively.

Procedures: Tissues were collected by surgical excision or at necropsy.

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In most mammals, glucokinase (GK) acts as a hepatic "glucose sensor" that permits hepatic metabolism to respond appropriately to changes in plasma glucose concentrations. GK activity is potently regulated by the glucokinase regulatory protein (GKRP), which is encoded by the GCKR gene. GKRP binds GK in the nucleus and inhibits its activity.

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