Publications by authors named "Orlando Carlos Conceicao-Neto"
Article Synopsis
- Enterobacter cloacae complex is a significant multidrug-resistant pathogen found in hospitals, prompting a study on its antimicrobial resistance and genetic factors in Brazil.
- The study screened 94 clinical isolates, finding 20.2% (19 isolates) resistant to colistin, with high levels of resistance indicated by MIC values ranging from 4 to 128 µg/mL.
- Genetic analysis revealed several carbapenemase and polymyxin resistance genes, along with diverse genetic profiles among the isolates, but no predominant clone was established.
Article Synopsis
- Carbapenems are crucial last-resort antibiotics for treating infections from multidrug-resistant Gram-negative bacteria, but resistance through mechanisms like OprD loss and carbapenemases is a growing global concern.
- A study in Brazil tested the effectiveness of three phenotypic tests—Carba NP, Blue Carba, and mCIM/eCIM—to detect carbapenemase-producing Pseudomonas species, using 127 clinical isolates.
- Results showed that Carba NP had the highest sensitivity and successfully differentiated between carbapenemases types, while Blue Carba struggled with class B detection, highlighting the need for improved and more reliable resistance detection methods.
Diagnosis of SARS-CoV-2 infections is mostly based on the nasopharyngeal swabs (NPS). However, this collection is invasive and uncomfortable, especially for children and patients with coagulopathies, whose NPS collection often causes bleeding. Thus, the aim of this study was to evaluate the usefulness and accuracy of saliva for the diagnosis of COVID-19 in patients presenting bleeding disorders.
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- Multidrug-resistant gram-negative bacilli (GNB) are a significant global health issue, especially when linked to bloodstream infections (BSI), which worsen patient outcomes.
- Whole-genome sequencing was used to study these pathogens in Brazil, revealing high-risk clones like CC258, ST79, and ST233, along with their resistance mechanisms.
- Key findings included associations between specific gene variants and clones, the identification of new MDR clone ST3079, and a novel clonal profile ST848, which could inform future strategies for managing BSI and other hospital-acquired infections.
Article Synopsis
- - Emergence of colistin-resistant bacteria with mobile resistance genes is a growing threat to both animals and humans involved in food production.
- - The article focuses on identifying a specific plasmid that carries colistin resistance genes in poultry, highlighting its role as a new reservoir for these genes.
- - Three closely related bacterial strains were isolated from cloacal swabs, and their genomes included a significant plasmid that potentially facilitates the spread of colistin resistance.
Epidemiology and antibiotic resistance trends in clinical isolates of Pseudomonas aeruginosa from Rio de janeiro - Brazil: Importance of mutational mechanisms over the years (1995-2015).
Infect Genet Evol
September 2019
Article Synopsis
- * A study in Rio de Janeiro analyzed 88 P. aeruginosa isolates from 1995 to 2015, revealing a shift from earlier MDR strains to more resistant extensive drug-resistant (XDR) strains in recent years, particularly with increased resistance to critical antibiotics.
- * Key resistance mechanisms identified included mutations in specific genes and the presence of carbapenemase genes, indicating a growing threat from high-risk clones of P. aeruginosa in the region.
New Delhi metallo-β-lactamase (NDM)-producing bacteria have been identified at a worrying rate in Brazil since 2013. Owing to the need to understand the extent of their spread, this study reports the dissemination of bla in different species of Gram-negative bacilli in different regions and states of Brazil. A total of 81 isolates from nine states were studied, including 11 species.
View Article and Find Full Text PDFBackground: Pulmonary deterioration after B.cepacia complex (BCC) colonization has a heterogeneous pattern. The aim was to investigate the clinical outcome of BCC colonization in CF patients chronically colonized with P.
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