The bacterial stringent response (SR) is a conserved transcriptional reprogramming pathway mediated by the nucleotide signalling alarmones, (pp)pGpp. The SR has been implicated in antibiotic survival in , a biofilm- and spore-forming pathogen that causes resilient, highly recurrent infections. The role of the SR in other processes and the effectors by which it regulates physiology are unknown.
View Article and Find Full Text PDFThe bacterial stringent response (SR) is a conserved transcriptional reprogramming pathway mediated by the nucleotide signaling alarmones, (pp)pGpp. The SR has been implicated in antibiotic survival in , a biofilm- and spore-forming pathogen that causes resilient, highly recurrent infections. The role of the SR in other processes and the effectors by which it regulates physiology are unknown.
View Article and Find Full Text PDFLeishmaniasis is a poverty-related disease endemic in 98 countries worldwide, with morbidity and mortality increasing daily. All currently used first-line and second-line drugs for the treatment of leishmaniasis exhibit several drawbacks including toxicity, high costs and route of administration. Consequently, the development of new treatments for leishmaniasis is a priority in the field of neglected tropical diseases.
View Article and Find Full Text PDFWe derive a cohomological formula for the analytic index of a family of Dirac-Ramond operators and exhibit its modular properties.
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