Publications by authors named "Oriol Ordi"
Article Synopsis
- Scientists don't know much about vulvar squamous cell carcinoma (VSCC), a cancer mostly found in older women, especially about its mutations and how different types affect survival.
- In a study of 60 patients, they found three main types of VSCC related to the human papillomavirus (HPV) and some common gene mutations, particularly in the TP53 gene.
- Patients with mutations in TP53 and CCND1 had a much higher chance of their cancer coming back, suggesting that these changes could help doctors find better treatments for VSCC.
Article Synopsis
- - Penile squamous cell carcinoma (PSCC) is divided into two main types: HPV-associated and HPV-independent, with the prognosis being influenced by the status of the p53 protein, which is somewhat debated.
- - A study involving 122 PSCC patients explored the correlation between HPV and p53 status, categorizing tumors into three subtypes based on immunohistochemistry and HPV tests.
- - Results showed that patients with HPV-independent tumors and abnormal p53 patterns had significantly worse outcomes, with a higher rate of disease-related deaths compared to those with HPV-associated or HPV-independent/p53-normal tumors.
p53 immunohistochemistry (IHC) has been proposed as a surrogate for mutations in penile squamous cell carcinomas (PSCC). We aimed to evaluate the performance of a pattern-based evaluation of p53 IHC in PSCC. Human papilloma virus (HPV) DNA testing, p16 and p53 IHC, and whole exome sequencing were performed in a series of 40 PSCC.
View Article and Find Full Text PDFBackground: Little evidence is available concerning the impact of virtual microscopy (VM) in the undergraduate teaching of pathology. We aimed: (1) to determine the impact in student scores when moving from conventional microscopy (CM) to VM; (2) to assess the students' impressions and changes in study habits regarding the impact of this tool.
Methods: We evaluated two groups taking the discipline of pathology in the same course, one using CM and the other VM.
Aims: Experience in the use of whole slide imaging (WSI) for primary diagnosis in pathology is very limited. We aimed to determine the accuracy of interpretation of WSI compared with conventional light microscopy (CLM) in the diagnosis of routine gynaecological biopsies.
Methods: All gynaecological specimens (n=452) received over a 2-month period at the Department of Pathology of the Hospital Clinic of Barcelona were analysed blindly by two gynaecological pathologists, one using CLM and the other WSI.