NH-sulfoximine: A novel pharmacological inhibitor of the mitochondrial F F -ATPase, which suppresses viability of cancerous cells.

Background And Purpose: The mitochondrial F F -ATPsynthase is pivotal for cellular homeostasis. When respiration is perturbed, its mode of action everts becoming an F F -ATPase and therefore consuming rather producing ATP. Such a reversion is an obvious target for pharmacological intervention to counteract pathologies.