Publications by authors named "Ori Wandel"
Article Synopsis
- - SARS-CoV-2 Omicron variant shows reduced clinical severity, prompting research into how its interactions with the respiratory tract affect this difference in pathogenicity.
- - In lab tests with human nasal and lung tissues, Omicron's replication in lung tissues is much more restricted compared to Delta and earlier variants, while remaining similar in nasal tissues.
- - Omicron triggers a stronger antiviral interferon response in lung tissues than Delta and earlier variants, suggesting that this enhanced immune response contributes to its lower severity; blocking this immune response can allow greater replication of Omicron in lungs.
Article Synopsis
- The nasal mucosa is the main entry point for respiratory viruses like SARS-CoV-2, but its early immune responses during infection have been largely overlooked.
- Research used human nasal and lung tissues to analyze how these sites respond to SARS-CoV-2 compared to influenza, revealing that the nasal mucosa mounts a strong antiviral response while lung tissues show a much weaker reaction.
- These findings indicate that targeting the nasal mucosa could be crucial for early intervention during SARS-CoV-2 infection, potentially preventing severe lung damage seen in advanced COVID-19 cases.
