A synthetic method to assay polycystin channel biophysics.

Ion channels are biological transistors that control ionic flux across cell membranes to regulate electrical transmission and signal transduction. They are found in all biological membranes and their conductive state kinetics are frequently disrupted in human diseases. Organelle ion channels are among the most resistant to functional and pharmacological interrogation.

A synthetic method to assay polycystin channel biophysics.

Ion channels are biological transistors that control ionic flux across cell membranes to regulate electrical transmission and signal transduction. They are found in all biological membranes and their conductive state kinetics are frequently disrupted in human diseases. Organelle ion channels are among the most resistant to functional and pharmacological interrogation.

Polycystin Channel Complexes.

Polycystin subunits can form hetero- and homotetrameric ion channels in the membranes of various compartments of the cell. Homotetrameric polycystin channels are voltage- and calcium-modulated, whereas heterotetrameric versions are proposed to be ligand- or autoproteolytically regulated. Their importance is underscored by variants associated with autosomal dominant polycystic kidney disease and by vital roles in fertilization and embryonic development.

Ferrocene tethered boramidinate frustrated Lewis pairs: stepwise capture of CO and CO.

The synthesis and reactivity of novel ferrocene tethered boramidinate frustrated Lewis pairs (FLPs), capable of the sequential capture of small molecules, is reported. Reactions of 1,1'-dicarbodiimidoferrocenes with different boranes provides access to metallocene tethered FLPs. The reactivity of the boramidinate moieties can be tuned by the nature of the carbodiimido substituents (alkyl aryl) and the borane used in the reduction (9-borabicyclo[3.

Irritable Bowel Syndrome Therapeutic Has Broad-Spectrum Antimicrobial Activity.

Otilonium bromide is a poorly absorbed oral medication used to control irritable bowel syndrome. It is thought to act as a muscle relaxant in the intestine. Here, we show that otilonium bromide has broad-spectrum antibacterial and antifungal activity, including against multidrug-resistant strains.

Antibacterial Thiamine inspired silver (I) and gold (I) N-heterocyclic carbene compounds.

Three new coinage metal carbene complexes of silver and gold were synthesized from a thiamine inspired ligand. The compounds were characterized by HRMS, NMR spectroscopy (H, F, P and C), FT-IR and elemental analysis. The coordination environment around the metal centers was correlated to the diffusion coefficients obtained from DOSY-NMR experiments and was in agreement with the nuclearity observed in the solid-state by single crystal X-ray crystallography.