Publications by authors named "Orhan Tunc Celiker"
Alzheimer's disease (AD) diagnosis relies on the presence of extracellular β-amyloid (Aβ) and intracellular hyperphosphorylated tau (p-tau). Emerging evidence suggests a potential link between AD pathologies and infectious agents, with herpes simplex virus 1 (HSV-1) being a leading candidate. Our investigation, using metagenomics, mass spectrometry, western blotting, and decrowding expansion pathology, detects HSV-1-associated proteins in human brain samples.
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- * To improve signal quality, researchers engineered cell-body-targeted versions of calcium indicators GCaMP6f and GCaMP7f that localize closer to neuron cell bodies in mice and zebrafish.
- * The use of soma-targeted GCaMP in one-photon imaging reduced crosstalk effects, resulting in clearer neural signals and less misleading correlations between neuron activity.