Impact of quetiapine on ion channels and contractile dynamics in rat ventricular myocyte.

Antipsychotic drugs often lead to adverse effects, including those related to the cardiovascular system. Of these, quetiapine is known to cause significant changes in the QT interval although the underlying mechanism remains mysterious, prompting us to examine its effects on cardiac electrophysiological properties. Therefore, we investigated the effect of quetiapine on contraction, action potential (AP), and the associated membrane currents such as L-type Ca and K using the whole-cell patch clamp method to examine its impacts on isolated rat ventricular myocytes.

Investigation of Cyclo-Z Therapeutic Effect on Insulin Pathway in Alzheimer's Rat Model: Biochemical and Electrophysiological Parameters.

Cyclo (his-pro-CHP) plus zinc (Zn) (Cyclo-Z) is the only known chemical that increases the production of insulin-degrading enzyme (IDE) and decreases the number of inactive insulin fragments in cells. The aim of the present study was to systematically characterize the effects of Cyclo-Z on the insulin pathway, memory functions, and brain oscillations in the Alzheimer's disease (AD) rat model. The rat model of AD was established by bilateral injection of Aβ42 oligomer (2,5nmol/10μl) into the lateral ventricles.

Pharmacological blockade of angiotensin II receptor restores diabetes-associated reduction of store operated Ca entry in adult cardiomyocytes.

The store-operated Ca entry (SOCE) represents an important route for generating cellular Ca signals that are implicated in physiological and various pathological scenarios that include diabetic cardiomyopathy (DM-CMP) which is well known to have Ca dysregulation among other salient features. In this study, we investigated the role of SOCE in Ca handling of cardiomyocytes obtained from adult male Wistar rats that were made diabetic by intraperitoneal administration of streptozotocin (STZ 50 mg/kg). We also included another group of rats with diabetes induced by STZ administration but received an angiotensin II receptor blocker - losartan.

Ellagic Acid Prevents Ca Dysregulation and Improves Functional Abnormalities of Ventricular Myocytes via Attenuation of Oxidative Stress in Pathological Cardiac Hypertrophy.

The aim of this study was to investigate whether ellagic acid (EA) treatment can prevent changes in contractile function and Ca regulation of cardiomyocytes in pathologic cardiac hypertrophy. Groups were assigned as Con group; an ISO group in which the rats received isoproterenol alone (5 mg/kg/day); and an ISO + EA group in which the rats received isoproterenol and EA (20 mg/kg/day) for 4 weeks. Subsequently, fractional shortening, intracellular Ca signals, and L-type Ca currents of isolated ventricular myocytes were recorded.

Rosuvastatin Reduces L-Type Ca Current and Alters Contractile Function in Cardiac Myocytes via Modulation of β-Adrenergic Receptor Signaling.

Rosuvastatin is one of the most used statins to lower plasma cholesterol levels. Although previous studies have reported remarkable cardiovascular effects of rosuvastatin (RSV), the mechanisms of these effects are largely unknown. In this study, we investigated the acute effects of RSV on L-type Ca currents and contractile function of ventricular myocytes under basal conditions and during β-adrenergic stimulation.

The effects of human amniotic membrane on silicone related capsule formation in rats.

Silicone breast implants are commonly used materials in plastic surgery for breast augmentation and reconstruction and the most severe complication of silicone implants are capsule contraction which occurs in 40% of patients. The aim of our study is to evaluate how the amniotic membrane alters the capsule formation effects of silicone 24 wistar rats were used in the study. We placed a bare silicone block into the left side (Subgroup A) and single layer amniotic membrane coated silicone block into the right side (Subgroup B) of the rats back.

Efficacy of positron emission tomography and computed tomography in clinical staging of cutaneous malignant melanoma.

Accurate staging is very important for determining the prognosis and appropriate treatment for malignant melanoma (MM). The aim of this study is to determine the effectiveness of positron emission tomography and computed tomography (PET/CT) imaging in staging MM. Patients diagnosed with MM who then underwent PET/CT metastasis before treatment were assessed retrospectively.

The effects of epidermal growth factor on early burn-wound progression in rats.

After burns, protecting tissues by medicines in the zone of stasis reduces the width and depth of injury. This study's goal was to reduce burned tissue damage in the zone of stasis using epidermal growth factor (EGF). Forty-eight Wistar rats were separated into three groups.

The effect of platelet-rich plasma in inactive form on the burn zone of stasis in rats.

The protection of the burn stasis zone tissues (BSZT) reduces the width and depth of the burn injury. In this study, it is aimed to show the effect of platelet-rich plasma (PRP) on the burn zone of stasis. Seventy-two Wistar rats were used in the study.

Transferring the protective effect of remote ischemic preconditioning on skin flap among rats by blood serum.

The aim of this study was to show whether the protective effect of remote ischemic preconditioning (RIPC) on flaps can be transferred among different individuals with the transfusion of blood serum. Blood serum was taken from rats without any procedure (Group x), rats 1 hour (Group y) and 24 hours (Group z) after performing RIPC and the remaining rats were divided into six groups. While the random pattern skin flap was performed only in the back region in Group 1, and it was performed 1 hour (Group 2) and 24 hours (Group 3) after induction RIPC.

A New Oval Advancement Flap Design for Reconstruction of Pilonidal Sinus Defect.

Backgrounds: Pilonidal sinus is a common chronic disease of the sacrococcygeal region. Although many surgical methods have been described for treating pilonidal sinus disease, controversy still exists as to the best surgical technique. The aim of this study is to present a new modified advancement flap technique named "omega flap" for the treatment of pilonidal sinus disease.

Collateral circulation between angiosomes in the feet of diabetic patients.

Objectives The main factor in the healing of foot ulcers in diabetic patients is adequate perfusion. There is no consensus on whether direct or indirect revascularization is more effective in leg revascularization. At the centre of that debate, there is a disagreement about whether collateral circulation is sufficient or not.

Effects of Remote Ischemic Conditioning Methods on Ischemia-Reperfusion Injury in Muscle Flaps: An Experimental Study in Rats.

Background: The aim of this study was to investigate the effects of remote ischemic conditioning on ischemia-reperfusion injury in rat muscle flaps histopathologically and biochemically.

Methods: Thirty albino rats were divided into 5 groups. No procedure was performed in the rats in group 1, and only blood samples were taken.

Using negative pressure therapy for improving skin graft taking on genital area defects following Fournier gangrene.

Objective: Fournier's gangrene is an infective necrotizing fasciitis of the perineal, genital and perianal regions. Treatment includes aggressive surgical debridement that often results in extensive loss of genital skin. Skin grafts may be used for reconstruction but skin grafting of the male genitalia is diffucult because the penis and scrotum are mobile and deformable.

The effect of intradermal administration of inactive platelet-rich plasma on flap viability in rats.

Purpose:: To evaluate the effect of inactive form of platelet rich plasma (PRP) on the flap viability.

Methods:: Thirty six rats were used. Rats were divided into six groups then 9x3 cm random pattern skin flaps were elevated from dorsum of all rats.

Efficacy of Liposuction as a Delay Method for Improving Flap Survival.

Background: Flaps are often used in repairing tissue defects and partial or full flap loss is still an important morbidity cause. Several techniques have been tried to increase flap circulation but none of these could replace the delay technique. Our goal in this study is to show the efficacy of liposuction in delay of dorsal rat cutaneous flaps and improvement in flap survival.

The protective effect of cilostazol on transverse rectus abdominis myocutaneous flap in rats.

Objective: Transverse Rectus Abdominis Myocutaneous (TRAM) flap is commonly used in breast reconstruction. The aim of this study is to demonstrate the effects of cilostazol on TRAM flap viability in a rat TRAM model.

Methods: Twenty-four Wistar rats were used.

Idiopathic bilateral central giant cell reparative granuloma of jaws: a case report and literature review.

Objectives: The central giant-cell reparative granuloma has been defined as a localized benign but sometimes aggressive osteolytic proliferation consisting of fibrous tissue with hemorrhage and hemosiderin deposits, presence of osteoclast-like giant cells and reactive bone formation. It is a benign lesion usually appears as solitary, multilocular, radiolucencies, located in the mandible and maxilla. Multiple CGCRGs of the jaw bones is very rare and, if it occurs, it is usually associated with hyperparathyroidism in majority of the cases .

Antibiotic use in abdominoplasty: prospective analysis of 207 cases.

The increasing demand for plastic surgery of the abdomen has also increased the number of complications, some of them very difficult to manage. It has been stated that antibiotics are unquestionably effective in preventing postoperative wound infections. In the present study, we aimed to provide guidelines for the use of prophylactic antibiotics in abdominoplasty operations.