- This study explored the impact of taxol on the inner ear of mice, analyzing 112 ears from 56 albino Swiss mice to assess how different doses affect hearing levels.
- Mice treated with taxol experienced significant hearing loss regardless of the dosage, with the control group showing no abnormalities, while treated groups demonstrated notable histopathological changes in their cochlea.
- The findings conclude that taxol leads to mild to moderate sensorineural hearing loss in mice, with initial effects observed at doses of 20 mg/kg or lower, and recommend monitoring hearing before treatment.