Publications by authors named "Orestis Mallis Kyriakides"
Article Synopsis
- Electrochemotherapy (ECT) uses electroporation alongside chemotherapeutic drugs like bleomycin (BLM) to treat colorectal liver metastases, evaluated in a rat study.
- Three groups of rats received ECT with either intravenous (i.v.), intratumoral (i.t.), or a combination of both methods for BLM injection, and various tumor metrics were measured post-treatment.
- Results indicated that both i.v. and i.v. + i.t. groups had significantly reduced tumor oxygen saturation compared to the i.t. group, but overall tumor necrosis and other tumor characteristics were similar across all treatments, suggesting i.v. administration may be the best option in clinical practice.
Background: The available ablative procedures for the treatment of hepatic cancer have contraindications due to the heat-sink effect and the risk of thermal injuries. Electrochemotherapy (ECT) as a nonthermal approach may be utilized for the treatment of tumors adjacent to high-risk regions. We evaluated the effectiveness of ECT in a rat model.
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