Publications by authors named "Oren Hillel"
Pregnancy worsens renal function in females with chronic renal failure (CRF) through an unknown mechanism. Reduced nitric oxide (NO) generation induces renal injury. Arginine transport by cationic amino acid transporter-1 (CAT-1), which governs endothelial NO generation, is reduced in both renal failure and pregnancy.
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- Hyperuricemia leads to endothelial dysfunction by reducing the activity of endothelial nitric oxide synthase (eNOS), which is crucial for maintaining healthy blood vessels.
- Studies show that hyperuricemic conditions decrease the transport of arginine, an important amino acid for eNOS, but treatments with benzbromarone or arginine can restore this transport.
- The negative effects of hyperuricemia on blood vessel function can be mitigated by these treatments, while allopurinol does not show the same effectiveness, highlighting the need for targeted therapies.
Background: Travelers' diarrhea is the most common infectious disease afflicting travelers to developing countries. Most studies investigating the benefits of recommendations regarding the consumption of food and water have focused on short-term travelers. We investigated the benefits of adherence to the precautions from the World Health Organization (WHO) among long-term travelers.
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