Thromboelastographic phenotypes of fibrinogen and its variants: clinical and non-clinical implications.

Introduction: Thromboelastography (TEG), a widely used clinical point of care coagulation test, is poorly understood. To investigate its fibrin determinants we used normal and variant fibrinogen isolates.

Materials And Methods: We focused mainly on the TEG maximum signal amplitude (MA), a shear modulus and clot stiffness indicator.