Glucose-sensitive insulin with attenuation of hypoglycaemia.

The risk of inducing hypoglycaemia (low blood glucose) constitutes the main challenge associated with insulin therapy for diabetes. Insulin doses must be adjusted to ensure that blood glucose values are within the normal range, but matching insulin doses to fluctuating glucose levels is difficult because even a slightly higher insulin dose than needed can lead to a hypoglycaemic incidence, which can be anything from uncomfortable to life-threatening. It has therefore been a long-standing goal to engineer a glucose-sensitive insulin that can auto-adjust its bioactivity in a reversible manner according to ambient glucose levels to ultimately achieve better glycaemic control while lowering the risk of hypoglycaemia.

Ileorectal anastomosis in ulcerative colitis: what do surgeons and patients need to know? A systematic literature review.

Introduction: Ileal pouch-anal anastomosis (IPAA) is currently the gold standard for restoration of gastrointestinal continuity after colectomy for ulcerative colitis in the UK. However, with further experience of the risks relating to IPAA, the use of ileorectal anastomosis (IRA) is being revisited. Decisions regarding restorative surgery after colectomy are individual to every patient's circumstances, and this paper aims to provide a comprehensive review of the literature to guide a full discussion of the risks and benefits of IRA.

Autonomous Sensor System for Low-Capacity Wind Turbine Blade Vibration Measurement.

This paper presents the design, implementation, and validation of an on-blade sensor system for remote vibration measurement for low-capacity wind turbines. The autonomous sensor system was deployed on three wind turbines, with one of them operating in harsh weather conditions in the far south of Chile. The system recorded the acceleration response of the blades in the flapwise and edgewise directions, data that could be used for extracting the dynamic characteristics of the blades, information useful for damage diagnosis and prognosis.

The value of pre-operative outpatient flexible sigmoidoscopy in patients with deep infiltrating endometriosis.

Background: Deep infiltrating endometriosis (DE) is a particularly severe disease which affects 10-20% of women with endometriosis. 90% of DE is rectovaginal and when suspected, some clinicians have suggested the routine use of flexible sigmoidoscopy to identify intraluminal disease. We aimed to assess the value of sigmoidoscopy prior to surgery for rectovaginal DE, both in terms of diagnosis and planning management.

Near-instantaneous battery End-of-Discharge prognosis via uncertain event likelihood functions.

The prediction of the time of occurrence of future events has been studied for decades in various scientific disciplines. Such events have historically been defined as moments where variables of interest (or indicators) hit pre-determined thresholds (i.e.

Extending the integrate-and-fire model to account for metabolic dependencies.

It is widely accepted that the brain, like any other physical system, is subjected to physical constraints that restrict its operation. The brain's metabolic demands are particularly critical for proper neuronal function, but the impact of these constraints continues to remain poorly understood. Detailed single-neuron models are recently integrating metabolic constraints, but these models' computational resources make it challenging to explore the dynamics of extended neural networks, which are governed by such constraints.

Adaptive passivity-based control extended for unknown control direction.

This research extends the design of adaptive passivity-based controllers (APBC), proposing a normalized APBC (NAPBC) for nonlinear dynamical systems with a direction of control unknown. The plant also has an accessible single-input and a single-output, smooth behavior, linear explicit parametric dependence, and unknown parameters. The proposed method can handle unknown control direction through an alternate and more straightforward method than Nussbaum gains, having two fewer parameters.

Out on the streets - Crisis, opportunity and disabled people in the era of Covid-19: Reflections from the UK.

Governments have responded to the Covid-19 crisis through various measures designed to reduce transmission and protect people judged to be at heightened risk. This paper explores the implications of such measures in the UK for disabled people, with a particular focus on measures designed to reduce and reshape the use of streets and public space. We divide UK measures into two broad categories.

Osteogenesis imperfecta mutations in plastin 3 lead to impaired calcium regulation of actin bundling.

Mutations in actin-bundling protein plastin 3 (PLS3) emerged as a cause of congenital osteoporosis, but neither the role of PLS3 in bone development nor the mechanisms underlying PLS3-dependent osteoporosis are understood. Of the over 20 identified osteoporosis-linked PLS3 mutations, we investigated all five that are expected to produce full-length protein. One of the mutations distorted an actin-binding loop in the second actin-binding domain of PLS3 and abolished F-actin bundling as revealed by cryo-EM reconstruction and protein interaction assays.

Online joint estimation and prediction for system-level prognostics under component interactions and mission profile effects.

Failure prognostics has become a central element in predictive maintenance. In this domain, the accurate determination of the remaining useful life (RUL) allows making effective maintenance and operation decisions about the assets. However, prognostics is often approached from a component point of view, and system-level prognostics, taking into account component interactions and mission profile effects, is still an underexplored area.

Liar! Liar! (when stakes are higher): Understanding how the overclaiming technique can be used to measure faking in personnel selection.

Overclaiming questionnaires (OCQs), which capture or exaggerating one's knowledge about a given topic, have been proposed as potentially indicative of faking behaviors that plague self-report assessments in job application settings. The empirical evidence on the efficacy of OCQs in this respect is inconsistent, however. We draw from expectancy theory to reconcile these inconsistencies and identify the conditions under which overclaiming behavior will be most indicative of faking.

Harvest Stage Recognition and Potential Fruit Damage Indicator for Berries Based on Hidden Markov Models and the Viterbi Algorithm.

This article proposes a monitoring system that allows to track transitions between different stages in the berry harvesting process (berry picking, waiting for transport, transport and arrival at the packing site) solely using information from temperature and vibration sensors located in the basket. The monitoring system assumes a characterization of the process based on hidden Markov models and uses the Viterbi algorithm to perform inferences and estimate the most likely state trajectory. The obtained state trajectory estimate is then used to compute a potential damage indicator in real time.

A biomimetic receptor for glucose.

Specific molecular recognition is routine for biology, but has proved difficult to achieve in synthetic systems. Carbohydrate substrates are especially challenging, because of their diversity and similarity to water, the biological solvent. Here we report a synthetic receptor for glucose, which is biomimetic in both design and capabilities.

A systematic review of McKittrick-Wheelock syndrome.

Introduction: McKittrick-Wheelock syndrome describes the condition of extreme electrolyte and fluid depletion caused by large distal colorectal tumours, usually the benign villous adenoma. Patients generally present critically unwell with severe hyponatraemia, hypokalaemia and/or acute kidney injury.

Methods: A structured literature review was undertaken to discover what is known about this condition, which is almost universally described as rare.

Turning is an important marker of balance confidence and walking limitation in persons with multiple sclerosis.

The standard functional tool for gait assessment in multiple sclerosis (MS) clinical trials has been the 25-Foot Timed Walk Test, a measure of gait speed. Straight-line gait assessment may not reflect adequately upon balance and coordination. Walking tests with turns may add additional information towards understanding gait and balance status, and be more reflective of ambulation in the community.

"Will she live a long happy life?" Parents' concerns for their children with Fontan circulation.

Background: Families of children at the worst end of the congenital heart disease endure a significant burden which is often not clearly delineated in the clinical literature. We examined the greatest concerns of parents whose children have a Fontan circulation.

Methods: Parents ( = 107) of children in the Australian and New Zealand Fontan Registry completed online surveys with open-ended and closed questions.

Advanced strategies to improve nitrification process in sequencing batch reactors - A review.

The optimization of biological nitrogen removal (BNR) in sequencing batch reactors has become the aim of researchers worldwide in order to increase efficiency and reduce energy and operating costs. This research has focused on the nitrification phase as the limiting reaction rate of BNR. This paper analyzes different strategies and discusses different tools such as: factors for achieving partial nitrification, real-time control and monitoring for detecting characteristic patterns of nitrification/denitrification as end-points, use of modeling based on activated sludge models, and the use of data-driven modeling for estimating variables that cannot be easily measured experimentally or online.

"How long will I continue to be normal?" Adults with a Fontan circulation's greatest concerns.

Background: Little is known about adults living with a Fontan circulation's concerns outside the scope of their clinical outcomes. We examined adults with a Fontan circulations' greatest concerns, as well as their concerns around anti-coagulation, pregnancy and finances.

Methods: Adults with a Fontan circulation in the Australian and New Zealand Fontan Registry were invited to complete an anonymous online survey, of which 57 participated.

A new Lower Triassic ichthyopterygian assemblage from Fossil Hill, Nevada.

We report a new ichthyopterygian assemblage from Lower Triassic horizons of the Prida Formation at Fossil Hill in central Nevada. Although fragmentary, the specimens collected so far document a diverse fauna. One partial jaw exhibits isodont dentition with blunt tipped, mesiodistally compressed crowns and striated enamel.

Social and behavioural factors in Non-suspicious unexpected death in infancy; experience from metropolitan police project indigo investigation.

Background: Risk factors for Sudden Unexpected Death in Infancy (SUDI) are well described, and such cases are now investigated according to standard protocols. In London, Project Indigo of the Metropolitan Police provides a unique, detailed framework for such data collection. We investigate such data to provide a contemporary account of SUDI in a large city and further link data to publically available datasets to investigate interactions with social factors.

The impact of healthcare rationing on elective and emergency hernia repair.

Purpose: In 2011 the local clinical commissioning group introduced a policy restricting funding for elective hernia repairs. Anecdotally, it was felt that this resulted in an increased number of emergency hernia repairs in our trust. Our primary objective was to assess whether this was actually the case.

Number and location of drainage catheter side holes: in vitro evaluation.

Aim: To evaluate the influence of number and location of catheter shaft side holes regarding drainage efficiency in an in vitro model.

Materials And Methods: Three different drainage catheter models were constructed: open-ended model with no side holes (one catheter), unilateral side hole model (six catheters with one to six unilateral side holes), and bilateral side hole model (six catheters with one to six bilateral side holes). Catheters were inserted into a drainage output-measuring device with a constant-pressure reservoir of water.

In vitro evaluation of the insertion force for different dilator tip configurations.

The purpose of this study was to evaluate the tissue penetration insertion force of different dilator tip geometries in simulated tissue. Four different dilator tip designs-conical (control), triangular, diamond, and biconvex-were appraised. The penetration force for each dilator was measured by using an ad hoc device.

Model combustion-generated particulate matter containing persistent free radicals redox cycle to produce reactive oxygen species.

Particulate matter (PM) is emitted during thermal decomposition of waste. During this process, aromatic compounds chemisorb to the surface of metal-oxide-containing PM, forming a surface-stabilized environmentally persistent free radical (EPFR). We hypothesized that EPFR-containing PM redox cycle to produce ROS and that this redox cycle is maintained in biological environments.