Publications by authors named "Orcel P"

Article Synopsis
  • Fibrodysplasia ossificans progressiva (FOP) is a rare disorder causing painful flare-ups and abnormal bone growth, known as heterotopic ossification (HO).
  • In a clinical trial, patients receiving the anti-activin A antibody garetosmab experienced fewer severe and lengthy flare-ups compared to those given a placebo, leading to a notable difference in quality of life.
  • The study found that 71% of placebo patients had flare-ups linked to new HO lesions, while garetosmab reduced the severity, duration, and frequency of these flare-ups throughout the trial.
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Background: There are several therapeutic options for the management of shoulder adhesive capsulitis (AC). The superiority of arthro-distension over intra-articular steroid injection (ISI) for AC remains controversial.

Objectives: To evaluate the efficacy of a single arthro-distension procedure combined with early and intensive mobilization (ADM) and physiotherapy, versus ISI and physiotherapy, in people with AC lasting ≥3 months.

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Article Synopsis
  • Slow-flow vascular malformations often have mutations in the PI3K/AKT/mTOR pathway, prompting the need for effective drug therapies like sirolimus, which has shown promise in prior trials.
  • The VASE trial is a large-scale, ongoing phase III study initiated in 2016, assessing the efficacy and safety of sirolimus over 2 years in both pediatric and adult patients with these conditions.
  • Preliminary results show that 85% of patients experienced clinical improvement, with some adverse effects reported; however, many patients experienced a recurrence of symptoms after treatment ended.
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Article Synopsis
  • - Fibrodysplasia ossificans progressiva (FOP) is a rare condition that causes painful heterotopic ossification in connective tissues, leading to disability.
  • - In the LUMINA-1 phase 2 trial, adults with FOP were given either garetosmab (an activin A-blocking antibody) or a placebo over two 28-week periods, focusing on safety and effects on HO lesions.
  • - Although the primary efficacy endpoint was not met in the first period, garetosmab significantly reduced the development of new HO lesions in the second period compared to placebo, with ongoing investigations into its effectiveness.
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Objectives: Low back pain (LBP) is one of the main expenditure items for health systems. Data on the economic impact of LBP are uncommon from the patient perspective. The aim of this study was to estimate the economic impact of work disability related to chronic LBP from the patient perspective.

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Background: Information is lacking on the natural history of early stages of degenerative rotator cuff disease. Such information can be obtained by using clinical and imaging assessment after conservative treatment in affected patients.

Hypothesis: Subacromial impingement syndrome is a clinical presentation that can be associated with early stages of the disease.

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Background: Dynamic humeral centering (DHC) is a physiotherapy modality that aims to prevent sub-acromial impingement of rotator cuff tendons. We recently developed a new clinical manoeuver - the Viggo-Cochin test - to enhance the ability of the Neer test to detect sub-acromial impingement. Here we hypothesised whether the DHC effect may differ between individuals with positive and negative Viggo-Cochin test results.

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Article Synopsis
  • * The TOCIDYS trial involved 16 patients over a year, measuring serum CTX and other bone health indicators, as well as changes in bone pain and quality of life, but faced some dropout and complications in patient adherence.
  • * Results showed no significant differences in bone turnover markers, pain levels, or quality of life between the tocilizumab and placebo groups, although some individual patients reported pain
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Unlabelled: This observational study prospectively assessed direct and indirect costs related to patient management over 18 months following hip, clinical vertebral, humeral, or distal forearm fracture events in France. It appears that their levels were much higher than the previous estimates, raising the burden of osteoporosis-related fractures on public health expenditures.

Introduction: This prospective observational study assessed the costs related to patient management over the 18-month period following the event of a hip, clinical vertebral, humeral, or distal forearm fracture in France.

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Background: Early-onset osteoporosis (EOOP) is defined by low bone mineral density (BMD), which increases the risk of fracture. Although the prevalence of osteoporosis at a young age is unknown, low BMD is highly linked to genetic background. Heterozygous pathogenic variants in low-density lipoprotein receptor-related protein 5 (LRP5) are associated with EOOP.

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In achondroplasia, lumbar spinal stenosis arises from congenital dysplasia and acquired degenerative changes. We here aimed to describe the changes of the lumbar spinal canal and intervertebral disc in adults. We included 18 adults (age ≥ 18 years) with achondroplasia and lumbar spinal stenosis.

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Background: The diagnosis of adhesive capsulitis is currently based on restricted range of motion (ROM) but its diagnostic value has only been rarely investigated.

Aim: The aim of this study is to assess the diagnostic value of active global and passive gleno-humeral ROM to diagnose shoulder adhesive capsulitis.

Design: Cross-sectional descriptive study.

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Percutaneous vertebral augmentation/consolidation techniques are varied. These are vertebroplasty, kyphoplasty, and several methods with percutaneous introduction of an implant (associated or not with cement injection). They are proposed in painful osteoporotic vertebral fractures and traumatic fractures.

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Genetic determinants contribute to osteoporosis and enhance the risk of fracture. Genomewide association studies of unselected population-based individuals or families have identified polymorphisms in several genes related to low bone density, but not in osteoporotic patients with -score < -2.0 SD with fragility fracture(s).

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Objective:: To compare psychometric properties of Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire, Shoulder Pain and Disability Index (SPADI) and Constant-Murley scale, in patients with degenerative rotator cuff disease (DRCD).

Design:: Longitudinal cohort.

Setting:: One French university hospital.

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Purpose: Oncogenic osteomalacia is an endocrine disorder induced by small benign tumours (TIO) producing excessive fibroblast growth factor-23 (FGF23). The only way of curing oncogenic osteomalacia is surgical resection of the culprit TIO, which is extremely difficult to detect using conventional imaging modalities due to its small size and variable location in the body. Since TIO frequently overexpress somatostatin receptors, a clinical utility of SPECT or PET with radiolabelled somatostatin analogues has been reported.

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Background: The Neer, Hawkins, and Yocum clinical tests detect sub-acromial impingement as a pathogenic process of degenerative rotator cuff disease. Their reproducibility has been little investigated.

Objectives: We tested the reproducibility of the Neer, Hawkins, and Yocum clinical tests for detecting this sub-acromial impingement and also an original clinical manoeuver, the countertest with elevation with lateral rotation (CELR), which is a test of sub-acromial impingement.

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Objectives: To assess the efficacy of bisphosphonate therapy on bone pain in patients with osteoid osteoma (OO) (main objective), and to describe bisphosphonate-induced changes in nidus mineralisation and regional bone-marrow oedema (BMO).

Methods: A prospective, observational study was conducted from 2011 to 2014. Patients with risk factors for complications of percutaneous or surgical ablation or recurrence after ablation, were offered once monthly intravenous bisphosphonate treatment until significant pain alleviation was achieved.

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Article Synopsis
  • Serum 25-hydroxyvitamin D (25OHD) tests in France have surged by tenfold over the past decade, often for questionable reasons.
  • In 2013, the French National Authority for Health imposed limits on when these tests could be ordered, restricting them mainly to specific health conditions like rickets and certain cases in older adults.
  • The authors argue that there are additional valid reasons for testing, supported by research, and advocate for the continued reimbursement of serum 25OHD tests for broader clinical scenarios.
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