Development of molecular diagnostic platform for α -thalassemia 44.6 kb (Chiang Rai, -- ) deletion in individuals with microcytic red blood cells across Thailand.

Introduction: The α -thalassemia 44.6 kb or Chiang Rai (-- ) deletion has been reported in northern Thailand and is capable of causing hemoglobin (Hb) H disease and a lethal α-thalassemia genotype, Hb Bart's hydrops fetalis, in this region. However, there are no current data regarding the frequency of -- nationwide due to a lack of effective diagnostic assay.