Antimalarial potentials of Harms (leguminoseae) stem bark in infected mice.

Background: Malaria is a leading cause of death in Nigeria.

Aim: Antimalarial activity of stem bark was evaluated in mice with an objective to finding scientific evidence for its use as antimalarial remedy in South-east Nigeria.

Methods: Antiplasmodial activities of hydro-methanolic extract and solvent fractions (hexane, chloroform, ethyl acetate and aqueous) of stem bark against chloroquine-sensitive infected mice were determined using suppressive and curative procedures.

Potential antimalarial activity of Coccinia barteri leaf extract and solvent fractions against Plasmodium berghei infected mice.

Ethnopharmacological Relevance: Coccinia barteri (Hook. F.) is traditional used in Southeast of Nigeria in management of fever.

Analgesic and Antioxidant Activities of Stem Bark Extract and Fractions of Petersianthus macrocarpus.

Background: Petersianthus macrocarpus (Lecythidaceae) is widely used in the folk medicine in Nigeria to relieve pain and fever associated with malaria. This study evaluated the analgesic and antioxidant activities of the methanol extract and fractions of the stem bark of the plant.

Materials And Methods: The analgesic activity was determined in mice using hotplate and acetic acid-induced writhing models.

Evaluation of Antioxidant Properties of Phaulopsis fascisepala C.B.Cl. (Acanthaceae).

The antioxidant activities of crude extract of Phaulopsis fascisepala leaf were evaluated and compared with alpha-tocopherol and BHT as synthetic antioxidants and ascorbic acid as natural-based antioxidant. In vitro, we studied its antioxidative activities, radical-scavenging effects, Fe(2+)-chelating ability and reducing power. The total phenolic content was determined and expressed in gallic acid equivalent.