Publications by authors named "Or Hen"
Article Synopsis
- Sarcoidosis is a condition that causes chronic inflammation and the formation of granulomas, which can lead to varying outcomes; some patients have mild issues while others face severe complications and higher mortality risk.
- A retrospective cohort study analyzed data from Clalit Health Services to compare mortality rates between sarcoidosis patients and matched controls, revealing a significantly higher mortality rate (17.7% vs. 10.6%).
- The study found that younger patients (under 50) experienced the highest mortality risk shortly after diagnosis, with age, male gender, and higher comorbidity scores being key predictors of increased mortality.
Early psoriatic arthritis: when is the right time to start advanced therapy?
Ther Adv Musculoskelet Dis
July 2024
Despite significant advances in the treatment of psoriatic arthritis (PsA) in the last two decades, remission remains elusive and there is no cure. Evidence from rheumatoid arthritis (RA) confirming enhanced response and outcome from earlier treatment intervention suggests the plausibility of the window of opportunity in the pathogenesis of RA. Yet, data are lacking in PsA.
View Article and Find Full Text PDFObjective: Obesity and age are strongly linked to severe COVID-19 pneumonia where immunomodulatory agents including Janus kinase inhibitors have shown benefits but the efficacy of such therapy in viral pneumonia is not well understood. We evaluated the impact of obesity and age on survival following baricitinib therapy for severe COVID-19.
Methods: A post hoc analysis of the COV-BARRIER multicentre double-blind randomised study of baricitinib versus placebo (PBO) with an assessment of 28-day mortality was performed.
Article Synopsis
- The study aimed to evaluate how common bone erosions are in early psoriatic arthritis (PsA) patients using conventional radiography (CR) and ultrasound (US), and to compare the results from both methods.
- Researchers assessed 4,655 joints in 122 newly diagnosed PsA patients and found that CR detected more erosions (24.6%) compared to US (1.04%), with the fifth metatarsophalangeal joint being the most affected in both techniques.
- The findings suggest that while CR identified more erosions, both methods showed high agreement, highlighting the importance of focused US examinations for wrist, second metacarpophalangeal, and fifth metatarsophalangeal joints
Objective: To investigate the prevalence of poly-refractory rheumatoid arthritis (RA) defined as failure of all biological (b)/targeted synthetic (ts)-disease-modifying drugs (DMARDs). To further investigate whether patients with persistent inflammatory refractory RA (PIRRA) and noninflammatory refractory RA (NIRRA), determined by objective ultrasound (US) synovitis, have distinct clinical phenotypes in both EULAR difficult-to-treat RA (D2T-RA) and poly-refractory RA groups.
Methods: A cross-sectional study of 1,591 patients with RA on b/tsDMARDs that evaluated D2T-RA criteria and subclassified as poly-refractory if inefficacy/toxicity to at least one drug of all classes.
Introduction: The exact pathogenesis of fibromyalgia (FM) syndrome is unclear. However, various infectious have been implicated with the development of FM after their acute phase. We aimed to investigate the incidence of FM syndrome among convalesced individuals following hospitalization for Acute Coronavirus Disease-2019 (COVID-19).
View Article and Find Full Text PDFAutoimmune/inflammatory Syndrome Induced by Adjuvants (ASIA; Shoenfeld's syndrome) comprehends a group of autoimmune conditions that flourish in genetically predisposed individuals, following an external stimulus by the so-called adjuvants. Many adjuvants were described, such as vaccines, aluminum and other metals, silicone, tattoos, among others. Those conditions entail defined diseases, such as sarcoidosis and Sjogren's syndrome, and generalized complex symptoms, for example, fatigue, sleep disturbance, orthostatic intolerance, and other dysautonomic manifestations.
View Article and Find Full Text PDFObjective: To evaluate the effects of exposure to air pollution by NO(x) and SO(2) on the development of pulmonary function of children, characterized by different health status.
Methods: A cohort of 1181 schoolchildren from the 2nd to 5th grades, residing near a major coal-fired power plant in the Hadera district of Israel, were subdivided into three health status groups, according to the diagnosis given by a physician at the beginning of the study period in 1996: (a) healthy children; (b) children experiencing chest symptoms, and (c) children with asthma or spastic bronchitis. Pulmonary Function Tests (PFTs) were performed twice (in 1996 and 1999) and analyzed in conjunction with air pollution estimates at the children's places of residence and several potential confounders-height, age, gender, parental education, passive smoking, housing density, length of residence in the study area and proximity to the main road.