Qualitative and quantitative changes of bone marrow cells in sensitized rabbits.

Bone marrow of adult rabbits was dynamically investigated during the sensitization of animals with the complete Freund's adjuvant containing 10 per cent human gammaglobulins (five intramuscular injections of 1 ml adjuvant, one per week). Smears, imprints and paraffin sections from tibial and femoral bone marrow were examined in normal, unsensitized animals, and a week after the third, the fourth and the fifth antigenic stimulations. The differential count of about 10,000 elements of 20-25 smears and imprints allowed the establishment of normal and modified myelograms at each sacrificing term.

[Preliminary results of the use of a new derivative of rifamycin SV in the treatment of sarcoidosis].

Seven patients with advanced forms of mediastino-pulmonary sarcoidosis (involvement of the pulmonary parenchyma, and restrictive respiratory syndrome), confirmed by histopathologic investigation, have been treated with a new SV-rifamycin derivative, 1246-EH, or "Reprimum" without any other association. Reprimun was given in daily doses of 10 mg/kg of body weight for a period of two weeks, then, for another 4-5 weeks, the drugs was given intermittently in doses of 15 mg/kg of body weight twice weekly. Between two cycles of therapy a period of 14 days was free of drug administration.