Publications by authors named "Oprea Alexandru"

Article Synopsis
  • - Vasculitis is a rare condition that causes inflammation of blood vessels and can affect various body systems, making diagnosis and treatment challenging due to its diverse symptoms.
  • - Large vessel vasculitis (LVV), specifically giant cell arteritis (GCA) and Takayasu arteritis (TAK), can lead to severe health issues, and early detection is vital to prevent potential organ damage.
  • - Imaging techniques like CT angiography, ultrasound, MRI, and PET-CT play a crucial role in diagnosing LVV by showing signs of vessel wall changes, and a collaborative approach among healthcare professionals is essential for better patient care.
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Objective: To report our step-by-step technique for 3D laparoscopic radical nephrectomy and thrombectomy for a right renal tumor with level IV venous thrombus. Worldwide experience in minimally-invasive approach for such complex cases is limited.

Materials And Methods: A 66-year-old male was incidentally diagnosed with a right renal tumor.

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Article Synopsis
  • Transcatheter aortic valve replacement (TAVR) is a key treatment for older patients with severe aortic stenosis, and this study looks at how it affects the strain of both the left and right ventricles three months after the procedure.
  • The study involved 52 elderly patients who had TAVR, showing significant improvement in left ventricular global longitudinal strain (LV GLS) and ejection fraction after three months, while right ventricular strain showed no significant changes.
  • Additionally, baseline LV GLS significantly correlated with follow-up readings, but there were weak correlations with age and NT-proBNP levels after TAVR, suggesting further investigation into these relationships is needed.
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Introduction: Balloon-expandable (BE) and self-expandable (SE) prostheses are the main types of devices currently used in transcatheter aortic valve implantation (TAVI). Despite the different designs, clinical practice guidelines do not make any specific recommendation on the selection of one device over the other. Most operators are trained in using both BE and SE prostheses, but operator experience with each of the two designs might influence patient outcomes.

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Recent translational efforts in brain-machine interfaces (BMI) are demonstrating the potential to help people with neurological disorders. The current trend in BMI technology is to increase the number of recording channels to the thousands, resulting in the generation of vast amounts of raw data. This in turn places high bandwidth requirements for data transmission, which increases power consumption and thermal dissipation of implanted systems.

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is a rare yet particularly aggressive infective endocarditis pathogen. We describe a case of successfully managed double-valve infective endocarditis, in which the presumed source of bacteremia was a long-term tunneled central venous catheter used for hemodialysis.

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Article Synopsis
  • A 73-year-old woman experienced recurrent headaches and dizziness, leading to a referral to a cardiology department due to suspected significant stenosis in her left internal carotid artery, along with a past history of hypertension.
  • After normal neurological exams and lab tests, a neck vascular ultrasound revealed a low bifurcation in the left common carotid artery and a hypoplastic left internal carotid artery with a sinuous path.
  • A CT angiography confirmed these findings, showing an unusual anatomy of the left common carotid artery and revealed that the left vertebral artery originated directly from the aortic arch with a kinking trajectory.
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Objective: Paravalvular aortic regurgitation is an important independent mortality predictor in transcatheter aortic valve implantation (TAVI). Our study evaluated the association between paravalvular aortic regurgitation and mid-term mortality in relation with the learning curve, in patients with severe aortic stenosis who underwent transfemoral TAVI in the first 3 years since the establishment of the program.

Methods: Patients with severe aortic stenosis who underwent transfemoral TAVI between 2017 and 2020 were included in the analysis.

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Infective endocarditis (IE) may present with quite different aspects. Consequently, it's management involves a collaborative approach between several specialties. We analyzed the timing of surgery and the role of the "Endocarditis Team" in patients with IE.

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A multidisciplinary Heart Team (HT) is nowadays considered to be of great importance for a complete and accurate assessment of patients with stable coronary disease (CAD). This study evaluates the role of the HT approach in the selection of best therapeutic strategies for patients with stable CAD. The study included 200 patients with stable coronary artery disease.

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The study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients, intended for coated tablets preparation and further transfer to industrial scale. The work aimed to prove that an accurate control of the critical granulation parameters can level the input material variability and offer a user-friendly process control strategy. Moreover, an in-line Near-Infrared monitoring method was developed, which offered a real time overview of the moisture level along the granulation process, thus a reliable supervision and control process analytical technology (PAT) tool.

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Our previous studies demonstrated that rare-earth oxycarbonates LnOCO (Ln = La, Nd, and Sm) and rare-earth oxides LnO (Ln = Nd, Sm, Gd, Dy, Er, and Yb) are sensitive to CO and that hexagonal LaOCO is the best among them in terms of sensitivity, stability, and selectivity. In this study, we have conducted a comprehensive operando characterization on a hexagonal LaOCO based sensor for the basic understanding of the sensing mechanism. This was done by performing under actual operating conditions simultaneous DC resistance and work function changes measurements, AC impedance spectroscopy measurements, and simultaneous DC resistance and DRIFT spectroscopy measurements.

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Within the framework outlined in the first part of the review, the second part addresses attempts to increase receptor material performance through the use of sensor systems and chemometric methods, in conjunction with receptor preparation methods and sensor-specific tasks. Conclusions are then drawn, and development perspectives for gravimetric sensors are discussed.

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Popliteal venous aneurysms are rare vascular disorders associated with a high risk of pulmonary embolism. We present the case of a 56-year-old woman hospitalized for a third episode of unprovoked pulmonary embolism. Venous ultrasonography identified a popliteal aneurysm, repeatedly missed by two-point compression venous ultrasonography, which was eventually confirmed by a magnetic resonance examination.

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Yellow transparent single crystals of the new compound K2Pb(OCN)I3 were synthesized from a mixture of lead iodide and potassium cyanate through a solid-state reaction, which was controlled by the differential scanning calorimetry (DSC) technique. The single crystal X-ray refinement showed that K2Pb(OCN)I3 crystallizes in the cubic system (Fd3[combining macron]m, a = 16.295(2) Å, V = 4327(1) Å3, Z = 16 and R1 = 0.

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Semiconducting metal oxide (SMOX)-based gas sensors are indispensable for safety and health applications, for example, explosive, toxic gas alarms, controls for intake into car cabins, and monitor for industrial processes. In the past, the sensor community has been studying polycrystalline materials as sensors where the porous and random microstructure of the SMOX does not allow a separation of the phenomena involved in the sensing process. This led to conduction models that can model and predict the behavior of the overall response, but they were not capable of giving fundamental information regarding the basic mechanisms taking place.

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Background & Objectives: : The pathophysiological mechanisms involved in distal pressure changes following arteriovenous fistula (AVF) creation in patients with end-stage renal disease (ESRD) are not completely understood. This study was aimed to assess digital pressure changes post-AVF creation and to identify the factors that might influence these changes in ESRD patients.

Methods: : In this prospective study, 41 patients with ESRD underwent AVF creation.

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The scientific interest in gas sensors is continuously increasing because of their environmental, medical, industrial, and domestic applications. This has resulted in an increasing number of investigations being reported in the literature and communicated at conferences. The present review, organized in two parts, addresses the peculiarities of gas sensors based on mass-sensitive transducers, starting with their structure and functionality and progressing to implementation and specific use.

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Background: Neutrophil-to-lymphocyte ratio (NLR) has recently emerged as a useful predictor of cardiovascular risk and adverse outcomes. According to previous studies, an NLR >5 has the highest sensitivity and specificity for postoperative morbidity and mortality in cardiovascular disease. This study aims to evaluate the NLR in cases of infrarenal unruptured abdominal aortic aneurysm (uAAA) and ruptured abdominal aortic aneurysm (rAAA) and to assess the role of NLR as a prognostic marker of 30-day mortality in patients with uAAA and rAAA who underwent surgical repair.

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Background And Aims: Arteriovenous fistula (AVF) maturation failure rates remain high in patients with end-stage renal disease (ESRD). Although preoperative morphological and functional assessment of blood vessels by duplex ultrasonography (DUS) has been shown to improve AVF maturation, there is no consensus regarding the optimal vein (VD) and artery (AD) diameters to be universally used for AVF creation. To improve patient selection, set out to investigate if there is a correlation between preoperative VD/AD and clinical covariates, and postoperative AVF outcome.

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We assessed the veins histopathological characteristics and preexisting medical conditions before arteriovenous fistula (AVF) creation, and their correlation with AVF outcome and primary patency in patients with end-stage renal disease (ESRD). In this observational, prospective, mono-center study in Romania, patients with artery and venous diameters =2 mm and =2.5 mm, respectively, were enrolled.

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This report presents the surgical repair and postsurgical outcomes following a ruptured infrarenal aortic aneurysm with a maximum transverse diameter of 20 cm. Its association with acute lower limb motor deficit is rare. Open surgery of giant abdominal aortic aneurysms is often the only available treatment, favored over an endovascular approach in the presence of increased aneurysm size with dislodged abdominal organs, adhesions, and short and angled proximal infrarenal aortic neck, presenting significant additional surgical and anesthesiological challenges.

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