Publications by authors named "Ophelie LeJeune"
Dandruff/seborrhoeic dermatitis (D/SD) is characterized by Malassezia colonization, impaired barrier function with subsequent inflammation, resulting in dandruff and itching. Histamine is one of the biomarkers of pruritus now widely used in treatment efficacy trials. The exact mechanism leading to histamine release and pruritus is not yet clear.
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- The study examined the long-term effects of a new shampoo regimen to prevent relapses in scalp seborrheic dermatitis (SD), focusing on changes in biomarkers.
- Subjects underwent an intensive treatment phase followed by a maintenance phase, where one group continued with the investigational shampoo while the other switched to a neutral shampoo.
- Results showed significant improvement in SD symptoms during both phases, particularly in the group that continued using the investigational product, highlighting important correlations between clinical signs and various biomarkers related to inflammation and itching.
The aim of this study is to quantify D. folliculorum colonisation in rosacea subtypes and age-matched controls and to determine the relationship between D. folliculorum load, rosacea subtype and skin innate immune system activation markers.
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