Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis.

Mycobacterium tuberculosis (Mtb) causes 1.6 million deaths annually. Active tuberculosis correlates with a neutrophil-driven type I interferon (IFN) signature, but the cellular mechanisms underlying tuberculosis pathogenesis remain poorly understood.

Immunosuppression is a conserved driver of tuberculosis susceptibility.

( ) causes 1.6 million deaths a year . However, no individual mouse model fully recapitulates the hallmarks of human tuberculosis disease.