Corrigendum to "Toxicopathological, proinflammatory and stress response evaluation of extract in male Wistar rats" [Toxicol. Rep. 8 (2021) 1769-1776].

[This corrects the article DOI: 10.1016/j.toxrep.

Breast Cancer Phenotypes in Africa: A Scoping Review and Meta-Analysis.

Purpose: Africans have been associated with more aggressive forms of breast cancer (BC). However, there is a lack of data regarding the incidence and distribution of different subtypes on the basis of phenotypic classification. This scoping review and meta-analysis was undertaken to determine the distribution pattern of BC phenotypes (luminal, human epidermal growth factor receptor 2 [HER2]+, and triple-negative breast cancer [TNBC]) across the African region.

Early-life AFB1 exposure: DNA methylation and hormone alterations.

Aflatoxins are secondary metabolites of mold that contaminate food and feedstuff. They are found in various food including grains, nuts, milk and eggs. Aflatoxin B1 (AFB1) is the most poisonous and commonly found of the various types of aflatoxins.

Stage 2 Hypertension and Electrocardiogram Abnormality: Evaluating the Risk Factors of Cardiovascular Diseases in Nigeria.

Introduction: This study evaluated the status of stage 2 hypertension, abnormal ECG and their co-occurrence as possible risk factors of cardiovascular disease and their predictors in a Nigerian University population.

Methods: A total of 717 subjects participated in this study. Blood pressure (BP), resting electrocardiogram (ECG) and other clinical parameters were measured and categorised according to standard organisational guidelines.

Toxicopathological, proinflammatory and stress response evaluation of extract in male Wistar rats.

The present study was carried out to assess the oral safety, proinflammatory and stress response effect of aqueous leaf extract (TCA) in male Wistar rats. The acute and sub-acute oral toxicity of TCA was assessed using guidelines 423 and 407 of the Organisation for Economic Co-operation and Development (OECD), respectively. Signs of clinical toxicity, morbidity and mortality were observed.

Protective Role of Seed Extract in High-Fat High-Fructose-Fed Rats.

is a therapeutic herb used in ethnomedicine for the management of several disease conditions including diabetes. This study examined the potential palliative effect of aqueous seed extract of (APN) on dyslipidemia, hyperglycemia, oxidative stress, insulin resistance, and the expression of some metabolic genes in high-fat high-fructose-fed rats. Experimental rats (2 months old) were fed a control diet or a high-fat diet with 25% fructose (HFHF diet) in their drinking water for nine weeks.

Bisphenol A in Africa: A review of environmental and biological levels.

Bisphenol A (BPA) is a synthetic ubiquitous environmental toxicant present in many industrial and consumer products. BPA is recognized as an endocrine-disrupting chemical (EDC), and its mechanisms of perturbation of the physiological process include interference with hormone pathways and epigenetic modifications. An increase in industrial productions and food packaging across Africa has resulted in increased utilization of BPA-containing products with a concomitant increase in environmental bioaccumulation and human exposure.

Sm. Leaf Extracts Extenuates Free Radicals, Inflammation, and Diabetes-Linked Enzymes.

This study was carried out to assess the antioxidant, anti-inflammatory and antidiabetic effects of (Sm.) leaf extracts. Ethanolic (NLE) and aqueous (NLA) extract of leaves were prepared and assessed for their anti-inflammatory activity, antioxidant potential, -amylase and -glucosidase inhibitory activities, and the mechanism of enzyme inhibition using standard established methods.

GC-MS Analysis and Inhibitory Evaluation of Leaf Extracts on Major Enzymes Linked to Diabetes.

leaves are used in managing both diabetes mellitus and its complications in Southwest Nigeria. However, its inhibitory activity on enzymes implicated in diabetes is not very clear. This study investigated the inhibitory properties and mode of inhibition of leaf extracts on enzymes associated with diabetes.