Pharmacological composition based on bacteriocinnisin in experiments and .

Background: Antibiotic resistance is a global health problem related to the transmission of bacteria and genes between humans and animals. The development of new drugs with antimicrobial activity research is an urgent task of modern science.

Aim: The article presents data of and experiments on new pharmaceutical composition based on nisin.

[Emotional stress as a clinical model to study the pathogenesis of the initial phase of the general adaptation syndrome].

Introduction: General adaptation syndrome (GAS), the basis of the development of which is stress phenomenon, is an essential component of the pathogenesis of many diseases and syndromes. However, the patho genesis of GAS hitherto is considered exclusively from the endocrinological viewpoint. This relates primarily to the initial phase of the GAS, a clinical model for the study of which may be psycho-emotional stress (PES), which we studied using three groups of volunteers.

[African wild cat (Felis lybica Forster, 1780) in the Saratov Transvolga Region].

Analysis of the area limits where African wild cat was found as well as of published data on its distribution in the Saratov Transvolga Region demonstrated that the local range of this species extended and its northwestern limit advanced almost 1000 km to the Volga zoogeographical boundary.

[Influence of physical loading on the content of intestinal microflora endotoxin in blood plasma and immunity indices to endotoxin].

The content of endotoxin of Gram-negative bacteria and humoral and granulocytic immunity indices to endotoxin in sportsmen and untrained persons before and after undergoing physical load were studied. The study revealed that prior to physical load the content of intestinal microflora endotoxin in the blood stream of volunteer students increased and the humoral immunity indices to endotoxin decreased. Judging by the content of cortisol in the blood, the state of stress increased after a physical load.

[Effects of endotoxin of gram-negative intestinal microflora on adaptation to physical exercise].

The study of plasm concentration of endotoxin (ET), activity of antiendotoxinic immunity (AEI) and early adaptation to exercise in 61 athletes and 13 students who were not athletes has revealed correlation between the former two and the latter parameters. ET was elevated in all the examinees prior to exercise. In exercise maladaptation both athletes and non-athletes demonstrated high ET levels in blood plasm and low AEI.

[Abundance of Trans-Volga population of the great bustard (Otis tarda L.)].

We studied the abundance, spatial structure, and democratic parameters of the Trans-Volga population of great bustard as well as this species connection to the habitats during premigratory movements. The data were obtained by monitoring a test area of 1,200,000 hectares in 1998-2000. Time-related changes in the structure of great bustard habitats in Saratov Trans-Volga Region during the 20th century are described and the mechanisms underlying the changes in this species connection to the habitats under the influence of anthropogenic factors are proposed.

Analysis of Yersinia pestis chromosomal determinants Pgm+ and Psts associated with virulence.

The ability to absorb exogenous pigments (Pgm+) has, until now, been considered an established virulence factor of Yersinia pestis, the causative agent of plague. This property correlates with the sensitivity to the bacteriocin pesticin (Psts). Both functions are chromosomally encoded.

[The ability of fleas of synanthropic rodents and small gerbils to feed on human blood].

Experimental study of the ability of Ceratophyllus (Nosopsyllis) mokrzeckyi, C. (G.) laeviceps, X.

[Use of an aerodynamic foam quencher in the stab cultivation of mycelial fungi].

A scheme for automatic impulse foam breaking during biosynthesis of cephalosporin C in 0.63 m3 pilot plant fermenters was developed and tested. It was shown that the use of an aerodynamic foam breaker did not limit the antibiotic biosynthesis by oxygen and promoted stabilization of the foam level in the apparatus without chemical antifoamers and increased air supply.

[Growth rate of antibiotic-producing gram-negative bacteria on liquid nutrient media].

Glycerol-yeast medium No. 3 may be used as a seed medium in screening of antibiotic-producing strains among Acetobacter, Gluconobacter, Chromobacterium, Agrobacterium, and other genera. The medium is transparent.