Publications by authors named "Oonagh Pickering"

Article Synopsis
  • The study aimed to see if a large randomized controlled trial could effectively evaluate office hysteroscopy (OH) against standard treatment (ST) for retained pregnancy tissue (RPT) after miscarriage, particularly regarding future pregnancy outcomes.
  • Conducted at Birmingham Women's Hospital, the pilot study involved women who opted for non-surgical management of miscarriage and showed a diagnosis RPT in 33.3% of participants after a follow-up ultrasound.
  • Results indicated high participation and satisfaction rates among patients, suggesting that a future larger trial comparing OH and ST for treating RPT is both necessary and feasible.
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Importance: The evidence on the association between diet and miscarriage risk is scant and conflicting.

Objective: To summarize the evidence on the association between periconceptual diet and miscarriage risk in healthy women of reproductive age.

Data Sources: Electronic databases were searched from inception to August 2022 without restriction of regions, publication types, or languages.

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Background: Endometrial receptivity has been the focus of continuous research for over eight decades; however, current clinical practice lacks an accurate test of endometrial receptivity to allow the prediction of successful pregnancy. We aimed to characterize the endometrial metabolomic profiles of women who suffered recurrent miscarriage using discovery metabolomics and to set the foundation for the development of an endometrial receptivity test.

Methods: This was a prospective multicenter cohort study led by the Tommy's National Centre for Miscarriage Research in Birmingham.

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Unlabelled: The Tommy's National Centre for Miscarriage Research aims to support the diagnosis and treatment for couples suffering from recurrent miscarriage. Tommy's Net is an electronic data gathering tool, collecting miscarriage data and links with hospital Clinical Information System databases. The gathering of patient reported data is an important aspect, especially as data relating to pregnancy and miscarriage events are often left unreported.

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Article Synopsis
  • This study investigates the link between serum progesterone levels and the success of frozen embryo transfers (FET) in women trying to conceive.
  • By reviewing existing research, it finds that higher progesterone levels (below 10 ng/mL) significantly improve ongoing pregnancy rates and reduce miscarriage risks, particularly when using vaginal progesterone and blastocyst embryos.
  • The authors suggest that a certain level of progesterone is crucial for embryo implantation, and they recommend more clinical trials to see if higher doses of progesterone can enhance FET outcomes for women with low levels.
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Objective: To characterise the endometrial transcriptomic profiles of women who suffered recurrent miscarriage and to set the foundation for the development of an endometrial receptivity test that could predict the fate of subsequent pregnancies.

Study Design: This was a prospective multicentre cohort study performed at the Tommy's National Centre for Miscarriage Research in Birmingham, Saint Mary's Hospital in Manchester and Royal Devon & Exeter Hospital, United Kingdom. The study was conducted between December 2017 and December 2019.

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Women who have had repeated miscarriages often have uncertainties about the cause, the likelihood of recurrence, the investigations they need, and the treatments that might help. Health-care policy makers and providers have uncertainties about the optimal ways to organise and provide care. For this Series paper, we have developed recommendations for practice from literature reviews, appraisal of guidelines, and a UK-wide consensus conference that was held in December, 2019.

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Objective: To assess the women's views in relation to the characteristics of an endometrial receptivity test in the context of recurrent miscarriage with an overarching aim to guide the development of a Target Product Profile (TPP) based on minimum acceptable ("worst-case") and ideal ("best-case") features.

Study Design: This was a descriptive cross-sectional study involving a total of 131 women who answered questions related to the development of an endometrial receptivity test between December 2017 and May 2018. Women attending the recurrent miscarriage clinic at the Tommy's National Centre for Miscarriage Research in Birmingham, United Kingdom, were invited to participate.

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