Publications by authors named "Onyu Park"
Background: Malnutrition exacerbates the prognosis of various diseases; however, its specific impact on severe coronavirus disease (COVID-19) outcomes remains underexplored.
Methods: This multicenter study in Korea assessed the nutritional status of 1,088 adults with severe COVID-19 using the Geriatric Nutritional Risk Index (GNRI) based on serum albumin levels and body weight. The patients were divided into the GNRI>98 (no-risk) and GNRI≤98 (risk) groups.
Asthma is a chronic lung disease characterized by airway inflammation, hyperresponsiveness, and narrowing, with a risk of life-threatening attacks. Most current treatments primarily consist of inhalable steroids, which are not without adverse effects. Recently, there has been growing interest in alternative approaches to asthma management.
View Article and Find Full Text PDFPrevalence of new frailty at hospital discharge in severe COVID-19 survivors and its associated factors.
Tuberc Respir Dis (Seoul)
December 2024
Article Synopsis
- * Researchers analyzed clinical data from 669 patients admitted to the ICU, finding that 27.8% developed new frailty at discharge, with factors like older age and certain health conditions linked to this change.
- * The findings indicate that new frailty is relatively common in these patients and is associated with various health factors, highlighting the need for better post-hospital care.
COVID-19 pandemic was accompanied by many healthcare-related issues. Concrete national data regarding the care performance of critical ill cases of COVID-19 does not exist in Korea. The current study aimed to describe the treatment outcome and healthcare resource utilization of critically ill COVID-19 patients.
View Article and Find Full Text PDFArticle Synopsis
- - The study examines the usefulness of age-adjusted endothelial activation and stress index (age-EASIX) in predicting ICU mortality for critically ill COVID-19 patients in South Korea, based on data from 22 hospitals from January 2020 to August 2021.
- - It involved 908 patients, averaging 67.4 years old, with non-survivors showing a significantly higher log2 age-EASIX compared to survivors, indicating that age-EASIX correlates with ICU mortality risk.
- - The findings suggest that age-EASIX not only is significantly linked to ICU mortality but also outperforms the sequential organ failure assessment (SOFA) score in predicting outcomes for patients in ICU.
Article Synopsis
- Older age, particularly those over 80, is linked to worse outcomes in COVID-19 patients needing mechanical ventilation, with higher rates of organ dysfunction.
- A study collected data from 434 patients across 22 medical centers, revealing that geriatric patients had higher mortality rates and less aggressive treatment than those aged 65-79.
- Key factors influencing mortality included high creatinine levels and the use of specific life-sustaining treatments, emphasizing the need for tailored approaches to care for critically ill older patients.
Background: The coronavirus disease (COVID-19) pandemic has significantly strained global healthcare, particularly in the management of patients requiring mechanical ventilation (MV) and continuous renal replacement therapy (CRRT). This study investigated the characteristics and prognoses of these patients.
Methods: This multicenter retrospective cohort study gathered data from patients with COVID-19 across 26 medical centers.
Background: Limited data are available on the mortality rates of patients receiving extracorporeal membrane oxygenation (ECMO) support for coronavirus disease 2019 (COVID-19). We aimed to analyze the relationship between COVID-19 and clinical outcomes for patients receiving ECMO.
Methods: We retrospectively investigated patients with COVID-19 pneumonia requiring ECMO in 19 hospitals across Korea from January 1, 2020 to August 31, 2021.
Background: Results of studies investigating the association between body mass index (BMI) and mortality in patients with coronavirus disease-2019 (COVID-19) have been conflicting.
Methods: This multicenter, retrospective observational study, conducted between January 2020 and August 2021, evaluated the impact of obesity on outcomes in patients with severe COVID-19 in a Korean national cohort. A total of 1,114 patients were enrolled from 22 tertiary referral hospitals or university-affiliated hospitals, of whom 1,099 were included in the analysis, excluding 15 with unavailable height and weight information.
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) have become the world's most common liver diseases, placing a growing strain on healthcare systems worldwide. Nonetheless, no effective pharmacological treatment has been approved. The naturally occurring compound cyclo histidine-proline (His-Pro) (CHP) is an interesting candidate for NAFLD management, given its safety profile and anti-inflammatory effects.
View Article and Find Full Text PDFBackgruound: CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode of action remains to be elucidated.
Methods: KK-Ay mice, a type 2 diabetes mellitus (T2DM) model, were administered CycloZ either as a preventive intervention, or as a therapy.
Background: The limitation of activity due to dyspnea in chronic obstructive pulmonary disease (COPD) patients is affected by diaphragmatic dysfunction and reduced lung function. This study aimed to analyze the association between diaphragm function variables and forced expiratory volume in the first second (FEV1) and to estimate the clinical significance of diaphragm function in the correlation between COPD severity and lung function.
Methods: This prospective, single-center, cross-sectional observational study enrolled 60 COPD patients in a respiratory outpatient clinic.