Intra-articular Myxoma Arising from the Scapholunate Ligament: A Rare Cause of Dorsal Wrist Swelling.

The differential diagnosis of a dorsal wrist swelling includes ganglion, lipoma, cutaneous tumors, and benign peripheral nerve sheath tumors, with ganglions being the most common. We present the case of a myxoma arising from the dorsal scapholunate ligament mimicking a dorsal wrist ganglion. Volar wrist joint myxomas have been previously reported, but this is the first report of a myxoma arising from the dorsal side of the wrist joint.

Homing of mesenchymal stem cells: mechanistic or stochastic? Implications for targeted delivery in arthritis.

Mesenchymal stem cells (MSCs) are multipotent cells with the capacity to undergo chondrogenic differentiation. Systemically administered MSCs have been shown to preferentially accumulate at sites of tissue damage and inflammation, thus MSC-based therapy holds great promise for the treatment of inflammatory diseases such as RA. Modulation of MSC homing may allow targeted delivery of systemically administered MSCs to damaged articular cartilage, where they can suppress immune-mediated cartilage destruction and contribute to cartilage repair via a combination of chondrogenic differentiation and paracrine stimulation of intrinsic residual repair.