Publications by authors named "Onyedika Emmanuel Okpala"
Musculoskeletal infections (MIs) are among the most difficult-to-treat staphylococcal diseases due to antibiotic resistance. This has encouraged the development of innovative strategies, such as combination therapy, to combat MI. The aim of this study was to investigate the in vitro antistaphylococcal activity of anti-inflammatory drugs and the combined antimicrobial effect of celecoxib and oxacillin.
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- The human microbiome significantly impacts how effective and safe certain drugs are for individuals, suggesting that personalized medicine should consider microbial effects.
- The study introduces AGORA2, an updated computational resource that includes detailed data on 7,302 gut microorganism strains and their interactions with 98 different drugs, enhancing previous models.
- AGORA2 shows high accuracy in predicting how gut microbes alter drugs, and it can tailor drug conversion predictions based on microbiome data from patients with colorectal cancer, highlighting the importance of individual factors like age and sex.