Improved Accuracy and Reliability of PRIMARY Scoring Using Delayed [Ga] Ga-PSMA PET/CT Imaging.

Objectives: Delayed [Ga]Ga-prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) images show reduced PSMA uptake in benign lesions and increased PSMA uptake in malignant lesions. This study investigated the efficacy of PRIMARY scoring on [Ga]Ga-PSMA PET/CT images at standard versus delayed time points and assessed the potential added value of delayed imaging in PRIMARY scoring.

Methods: A total of 140 patients with biopsy results of International Society of Urological Pathology grade groups (ISUP) 1-2 who had standard (median 60 min) and delayed images (median 138 min) with [Ga]Ga-PSMA PET/CT before radical prostatectomy were included.

Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Neuroendocrine Tumors with Rapid On-Site Evaluation: Single-Center Experience.

Introduction: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a highly sensitive and accurate method for identifying pancreatic neuroendocrine tumors (PanNETs). However, research on grading and assessing the Ki67 proliferation index in FNA samples is limited.

Methods: This study analyzed 335 EUS-FNA cases performed between 2016 and 2022, of which 12 cases of PanNET were further evaluated.

Diagnostic Characteristics and Clinical Relevance of Incidental Hypermetabolic Breast Lesions Detected on F-FDG PET-CT: A Retrospective Evaluation.

Rationale And Objectives: The study aimed to evaluate demographic and radiological characteristics of breast incidentalomas found on 18-fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (F-FDG PET-CT) performed for extramammary indications.

Materials And Methods: A total of 12633 F-FDG PET-CT scans performed between January 1, 2018 and January 1, 2024, were retrospectively reviewed. Breast incidentalomas that had undergone breast imaging, tissue diagnosis, or at least 2-year radiological follow-up were included.

Circulating cancer-associated macrophage-like cells and macrophage-related cytokines in obese patients with advanced breast cancer who undergo neoadjuvant chemotherapy.

Cancer-associated macrophage-like cells (CAMLs) are rare, gigantic, and atypical circulating cells found exclusively in the peripheral blood of patients with solid cancers. Obesity-induced hypoxia attracts macrophages to the tumor microenvironment, where they contribute to establishing chronic inflammation, leading to cancer progression. We hypothesized that obese patients with advanced breast cancer may have CAML profiles different from those of nonobese patients, and these profiles may correlate with proinflammatory markers or other macrophage-related markers.

Epidemiology of Patient Record Duplication.

Objectives:  Duplicate patient records can increase costs and medical errors. We assessed the association between demographic factors, comorbidities, health care usage, and duplicate electronic health records.

Methods:  We analyzed the association between duplicate patient records and multiple demographic variables (race, Hispanic ethnicity, sex, and age) as well as the Charlson Comorbidity Index (CCI), number of diagnoses, and number of health care encounters.

Synthesis and Optical Characterization of Hydrazone-Substituted Push-Pull-Type NLOphores.

Two distinct families of NLOphores featuring hydrazone donors were synthesized using click-type [2 + 2] cycloaddition retroelectrocyclizations (CA-RE). Despite the limitations in the substrate scope, it was shown for the first time that hydrazone-activated alkynes could undergo reactions with TCNE/TCNQ. The electrochemical, photophysical, and second-order nonlinear optical (NLO) characteristics of the chromophores were analyzed utilizing experimental and computational approaches.

Does Varying Platelet-Rich Fibrin Centri̇fugati̇on Protocols Enhance New Bone Formati̇on in Extracti̇on Site?

Background: Finding a protocol that could prevent bone resorption and be implemented in clinical practice would be crucial in providing sufficient bone to replace missing teeth with implants.

Purpose: The study aimed to determine the effectiveness of different centrifugation platelet-rich fibrin (PRF) protocols in new bone formation and bone regenerative markers.

Study Design, Setting And Sample: This randomized clinical trial was conducted at Izmir Katip Çelebi Research Hospital, a population-based facility in Izmir, Turkey.

Evaluation and follow-up of patients diagnosed with hypophysitis: a cohort study.

Objective: Primary hypophysitis might be challenging to diagnose, and there is a lack of evidence regarding optimal treatment strategies due to rarity of the disease. We aim to investigate the clinical features and compare the outcomes of different management strategies of primary hypophysitis in a large group of patients recruited on a nationwide basis.

Design: A retrospective observational study.

Associations Between Radiation Oncologist Demographic Factors and Segmentation Similarity Benchmarks: Insights From a Crowd-Sourced Challenge Using Bayesian Estimation.

Purpose: The quality of radiotherapy auto-segmentation training data, primarily derived from clinician observers, is of utmost importance. However, the factors influencing the quality of clinician-derived segmentations are poorly understood; our study aims to quantify these factors.

Methods: Organ at risk (OAR) and tumor-related segmentations provided by radiation oncologists from the Contouring Collaborative for Consensus in Radiation Oncology data set were used.

Pyridine-2,6-Dicarboxylic Acid As a Facile and Highly Selective "Turn-Off" Fluorimetric Chemosensor for Detection of Cu (II) Ions in Aqueous Media.

Copper metal is third most abundant trace element in human body. Determination of Cu (II) ions is a burning topic in field of environment protection and food safety because of its significant impact on ecosystem. In this study, 2,6-pyridine dicarboxylic acid (PDA) has been explored as "turn-off" florescent probe for florescent detection of Cu (II) ions.

Zinc(II) coordination compound with N'-(pyridin-2-ylmethylene)nicotinohydrazide: Synthesis, crystal structure, computational and cytotoxicity studies.

In this work, we report on the synthesis of a novel zinc(II) coordination compound [ZnL] (1), which was readily obtained from the reaction of Zn(OAc)·2HO and N'-(pyridin-2-ylmethylene)nicotinohydrazide (HL) in methanol. Recrystallization of 1 from dimethylformamide under ambient conditions allowed to produce yellow block-like crystals of 1·HO. Complex 1·HO was characterized by FT-IR and H NMR spectroscopy, while its optical properties were studied by UV-vis and spectrofluorimetry in methanol.

Zygomatic Implant Length Measurement Without Excessive Flap Release: A Human Cadaver Study.

One of the most important steps in zygomatic implant surgery is to determine the implant length. This cadaver study aims to identify an alternative technique for determining the length of the implant in zygoma surgery without excessive elevation of the flap. A total of 30 cadavers were included in this study.

A Finite Element Analysis to Study the Stress Distribution on Distal Implants in All-on-Six Treatment Concepts as Affected Tilted and Short Implant.

The number of implants and their respective configurations for implant-supported treatment modalities have been studied for 4 implant-supported prostheses; however, it is not yet clear whether the use of tilting or short implants in rehabilitation would result in substantially improved bone/implant/prosthesis biomechanics in all-on-six concepts. This study compared the biomechanical behavior of tilted long implants and axially short implants to support fixed prostheses in an atrophic maxilla with all-on-six treatment concepts. Three different implant configurations were planned, and six models were obtained with posterior maxilla D3 and D4 bone densities in this study.

Treatment of Depression in Huntington's Disease: A Systematic Review.

Depression is a common psychiatric disorder among individuals with Huntington's disease (HD). Depression in HD and major depressive disorder appear to have different pathophysiological mechanisms. Despite the unique pathophysiology, the treatment of depression in HD is based on data from the treatment of major depressive disorder in the general population.

Evaluation of immunohistochemical expression of novel neuroendocrine marker INSM1 and histological tumor growth pattern in well-differentiated neuroendocrine tumors of the appendix: 15-year single tertiary center experience.

Introduction: Well-differentiated neuroendocrine tumors of the appendix (A-WDNET) are the most common neoplasms of the appendix but are rare and incidental. INSM1 is a novel transcription factor marker with high sensitivity and specificity for neuroendocrine differentiation. It may display architecturally diverse tumor growth patterns including solid, nest, insular trabecular, and acinar.

A dual-emitting Rhodamine B-encapsulated Zn-based MOF for the selective sensing of Chromium(VI).

A Rhodamine B-Zn-MOF composite (RhB-Zn-MOF) with dual emission intensity was synthesized through one pot synthesis by in-situ encapsulation of Rhodamine-B dye on a new Zn-MOF metal-organic framework [(Zn(OAc)(4-BrIPh) (1,10-phenonthroline)(HO)].HO, (4-BrIPh = 4-Bromoisophthalic acid). The synthesized encapsulated material was characterized by elemental analysis, FTIR, UV-Visible spectroscopy, TGA, single crystal and powder X-ray diffraction and photoluminescence spectroscopy.

Prediction of clinically significant prostate cancer by [ Ga]Ga-PSMA-11 PET/CT: a potential tool for selecting patients for active surveillance.

Purpose: In our study, our aim was to investigate the role of [ Ga]Ga-PSMA-11 PET /CT imaging in the diagnosis of clinically significant prostate cancer (csPCa) (ISUP GG 2 and higher) in patients initially diagnosed with ISUP GG 1 and 2 after prostate biopsy.

Materials And Methods: We retrospectively reviewed 147 patient records in whom [ Ga]Ga-PSMA-11 PET/CT imaging was performed preoperatively. All patients were initially diagnosed with ISUP GG 1 and 2 PCa by biopsy.

Intramolecular through-space charge transfer between benzofuran and ynone groups on a naphthalene spacer.

We have developed a new scaffold that exhibits an efficient intramolecular through-space charge transfer (CT). In this design, electron-rich benzofuran and electron-deficient ynone groups are placed strategically in proximity a naphthalene spacer. Charge transfer is supported by distinct CT bands in the visible region (>500 nm) in their UV-vis absorption and emission spectra.

Treatment of Severely Atrophic Maxilla by Using Zygomatic, Pterygoid, and Transnasal Implants.

For many decades the success of dental implants has been considered to be dependent predominantly on the quality and quantity of the patient's alveolar bone. Grafting procedures have been commonly used to rehabilitate severely atrophic jaws but these procedures have disadvantages such as long treatment duration, major surgery, the risk of morbidity in the donor area, and high treatment costs. Recently, the use of 4 zygomatic implants has become an important treatment option in the rehabilitation of extremely atrophic maxilla.

Synthesis, Crystal Structure and Fluorimetric Study of 2-phenylphthalazin-1(2H)-one: a Highly Selective Florescent Chemosensor for Detection of Fe and Fe Metal Ions.

A ligand, 2-phenylphthalazin-1(2H)-one (K), was synthesized by refluxing 2-formylbenzoic acid with phenyl hydrazine in presence of ethanol. FTIR, elemental analysis and single crystal XRD techniques were used to elucidate the structure. Fluorimetric turn-off response was recorded when solution of ligand (K) in DMF was treated with aqueous solution of Fe and Fe metal ions.

Determining The Role Of Radiation Oncologist Demographic Factors On Segmentation Quality: Insights From A Crowd-Sourced Challenge Using Bayesian Estimation.

Background: Medical image auto-segmentation is poised to revolutionize radiotherapy workflows. The quality of auto-segmentation training data, primarily derived from clinician observers, is of utmost importance. However, the factors influencing the quality of these clinician-derived segmentations have yet to be fully understood or quantified.

Biomedical applications of engineered heparin-based materials.

Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic backbone. Due to its fascinating chemical and physical properties, nontoxicity, biocompatibility, and biodegradability, heparin has been extensively used in different fields of medicine, such as cardiovascular and hematology. This review highlights recent and future advancements in designing materials based on heparin for various biomedical applications.

Comparison of the Micro-Shear Bond Strength of Resin Cements to CAD/CAM Glass Ceramics with Various Surface Treatments.

This study aimed to compare the effect of acid etching, sandblasting, or silica coating on the micro-shear bond strength of dual-cured resin cements to computer-aided design and computer-aided manufacturing (CAD/CAM) glass ceramic materials. Feldspathic, lithium disilicate, and zirconia-reinforced CAD/CAM ceramics were divided into four groups: control group (C), no surface treatment; hydrofluoric (HF) group, 5% HF acid-etched; sandblasting (SB) group, abraded with 50 µm aluminum oxide (AlO) particles; silica-coated (CJ) group, abraded with 30 µm silica-modified AlO particles. Roughness values were obtained by using a profilometer.