Publications by authors named "Onur E Taparli"
The intricate system of connections between the eye and the brain implies that there are common pathways for the eye and brain that get activated following injury. Hypoxia-ischemia (HI) related encephalopathy is a consequence of brain injury caused by oxygen and blood flow deprivation that may result in visual disturbances and neurodevelopmental disorders in surviving neonates. We have previously shown that the tyrosine receptor kinase B (TrkB) agonist/modulator improves neuronal survival and long-term neuroprotection in a sexually differential way.
View Article and Find Full Text PDFThe variability of severity in hypoxia-ischemia (HI)-induced brain injury among research subjects is a major challenge in developmental brain injury research. Our laboratory developed a novel injury scoring tool based on our gross pathological observations during hippocampal extraction. The hippocampi received scores of 0-6 with 0 being no injury and 6 being severe injury post-HI.
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- Patients with drug hypersensitivity often experience high levels of anxiety and depression, significantly affecting their quality of life (QoL).
- In a study, patients showed much higher anxiety (BAI) and depression (BDI) scores compared to healthy controls, with nearly half of the patients at risk for anxiety.
- The findings suggest that more severe hypersensitivity reactions correlate with higher psychological distress, emphasizing the need for psychological support to improve patient outcomes.