Publications by authors named "Ons Mihoub"
Article Synopsis
- The study investigates the link between soluble HLA-E isoforms and the risk and severity of schizophrenia and bipolar disorder in a Tunisian population.
- Findings indicate that bipolar disorder patients have significantly higher levels of sHLA-E, especially during acute phases, while schizophrenia patients show higher levels in stable conditions but not generally.
- The results support the idea that sHLA-E can be considered a reliable inflammatory marker for both disorders, confirming previous findings in a French cohort.
Objectives: Schizophrenia is a complex and chronic neuropsychiatric disorder. Recent genome-wide association studies have identified several at risk genetic variants, including two single nucleotide polymorphisms, namely the rs10503253 and the rs1270942 respectively located in the CSMD1 and the CFB loci. The present case-control study was designed to assess potential associations between the two variants and the risk of developing schizophrenia and disease severity.
View Article and Find Full Text PDFBackground And Study Aim: Schizophrenia (SZ) is a multifactorial disorder involving complex interactions between genetic and environmental factors, where immune dysfunction plays a key etiopathogenic role. In order to explore the control of innate immune responses in SZ, we aimed to investigate the potential association between twelve TLR2, TLR4 and TLR9 variants (TLR2: rs4696480T>A, rs3804099T>C, rs3804100T>C; TLR4: rs1927914G>A, rs10759932T>C, rs4986790A>G, rs4986791T>C, rs11536889G>C, rs11536891T>C; TLR9: rs187084A>G, rs352139T>C and rs352140C>T) and SZ susceptibility in a Tunisian population.
Patients And Methods: This study included 150 patients and 201 healthy controls with no history of psychiatric illness.
Article Synopsis
- Mitochondria are crucial for energy in cells, and their dysfunction may lead to issues like premature aging and inflammation, which are seen in bipolar disorder (BD).
- A study compared mitochondrial DNA copy number (mtDNAcn) in 312 BD patients across different mood phases (manic, depressive, euthymic) and 180 healthy controls, finding lower mtDNAcn in BD patients, especially during manic phases.
- Low mtDNAcn levels were associated with worse mood and psychotic symptoms, while being linked to higher inflammatory markers. These findings could help in predicting mood changes and improving treatment options for BD if confirmed.
Bipolar disorder is a chronic, disabling disease that is characterized by the recurrence of thymic episodes. The role of the immune-inflammatory system in the etiopathogenesis of this affection arouses the interest of research. The aim of this work was to determine the plasma levels of the high sensitivity C reactive protein (hs-CRP) in patients with bipolar disorder in remission phase by comparing them to a control group.
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