Publications by authors named "Ons Fekih"
Background: The aim of this study was to evaluate the association of ACE, angiotensinogen (AGT) and angiotensin II receptor type I (AGTR1) polymorphisms with diabetic nephropathy (DN) in Tunisians.
Methods: The study population comprised 236 type 2 diabetic patients: with nephropathy (DN = 47) and without nephropathy (DM = 189). Genotyping of ACE-I/D-rs1799752, ACE-rs4343G>A, AGT-rs5050A>C, AGT-rs 4762C>T, AGT-rs699A>G, and AGTR1-rs5186A>C was performed by PCR-RFLP.
Background: Elevated osteoprotegerin (OPG) levels have been reported in patients with diabetes complications. We investigated whether plasma OPG levels can be used as a marker of cardiovascular risk in children and adolescents with type 1 diabetes (T1D).
Methods: Plasma blood samples were obtained from 243 subjects (143 children and adolescents with T1D and 100 healthy controls).
Introduction: Paraoxonase 1 (PON1) polymorphisms have been largely involved in diabetes complications. The aim of the study is to evaluate the effects of PON1 polymorphisms (L55M and Q192R) on diabetic nephropathy (DN).
Material And Methods: The study involved 116 children and adolescents with type 1 diabetes (T1D) and 91 healthy subjects.
Article Synopsis
- - The study aimed to determine if paraoxonase 1 (PON1) activity could indicate cardiovascular risk in young Tunisian individuals with type 1 diabetes (T1D).
- - Researchers compared PON1 activity and various cholesterol levels in 109 T1D patients and 97 healthy controls, finding that diabetics had significantly lower PON1 activity and higher cholesterol levels.
- - The findings suggest that decreased PON1 activity correlates with an increased number of cardiovascular risk factors in T1D patients, indicating that improving PON1 activity might help reduce cardiovascular risk.
Background: Only a few studies have focused on the possible modulatory role of paraoxonase 1 (PON1) polymorphisms in lipid profiles, especially in children and in adolescents with type 1 diabetes (T1D).
Objective: We propose to study the association between PON1 polymorphisms (PON1-55 and PON1-192) and a lipid profile in a young Tunisian population with T1D.
Methods: The study compared 122 children and adolescents with T1D with 97 controls.
[Does bilirubin interfere with capillary electrophoresis of serum proteins?].
Ann Biol Clin (Paris)
October 2014
Capillary electrophoresis of serum proteins is a fast, reliable and simple technique, but many interference exist. The objective of our work is to study the interference of bilirubin on this technique; 70 icteric sera were analysed on Capillarys ™ (Sebia). A second electrophoresis was performed on 40 samples after bilirubin photodegradation.
View Article and Find Full Text PDFAssociation between serum cystatin C levels and cardiovascular disease in type 2 diabetic patients.
Ann Biol Clin (Paris)
November 2013
Serum cystatin C concentration was recently reported as a marker of cardiovascular disease (CVD). In the present study, we evaluated the association between the increase of serum cystatin C levels and the risk of CVD in type 2 diabetes. 42 patients with type 2 diabetes were included in the present study; 27 of them have CVD.
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