Melanin-producing medullary thyroid carcinoma with transformation to melanoma: A case report.

Only one case of melanoma arising from melanin-producing medullary thyroid carcinoma (MTC) has been reported previously. In the present study, a second such case was reported and compared with the previous one. The patient was an 86-year-old male who presented with a right anterior neck mass.

Clinicopathologic Characteristics and A20 Mutation in Primary Thyroid Lymphoma.

Background: Primary thyroid lymphoma (PTL) is a rare disease frequently arising against a background of autoimmune thyroiditis. It has recently been reported that the inactivation of the NF-κB negative regulator A20 by deletion and/or mutation could be involved in the pathogenesis of subsets of B-cell lymphomas. This study investigated the clinicopathologic characteristics and A20 mutation in patients with PTL.

Properties of heat-sensitive neurons in the premotor cortex of conscious monkeys.

To investigate neuronal activity involved in responses to noxious stimuli in conscious monkeys, the animals were subjected to a task that required them to detect a small change in facial skin temperature or light (second temperature: T2, second light: V2) relative to an initial condition (T1 or V1), and to detect changes in V2 along with a heat task. Recordings were obtained from 57 neurons in the ventral premotor cortex (PMv) during the heat or light detection task. T1 neurons and T2 neurons showed increased activity only during T1 or T2, and T1/T2 neurons were activated by both T1 and T2 stimuli.

Influence of Short-Term Dietary and Therapeutic Iodine Restriction on the Therapeutic Effects of Radioactive Iodine Therapy in Patients with Graves' Disease.

Several studies have investigated the factors affecting the effects of radioactive iodine (I) treatment (RAIT) in patients with Graves' disease. However, the influence of dietary or therapeutic iodine on the effect of RAIT has not been fully elucidated yet. The aim of this study was to investigate whether dietary or therapeutic iodine before RAIT influences the therapeutic effects of RAIT with a fixed-dose regimen and a short-term restriction of iodine intake in an iodine-sufficient area.

Exosomes Expressing Thyrotropin Receptor Attenuate Autoantibody-Mediated Stimulation of Cyclic Adenosine Monophosphate Production.

Exosomes or small extracellular vesicles secreted from cells are nanovesicles with a diameter of 40-150 nm, which play a number of roles in both physiologic and pathologic processes. In Graves' disease (GD), autoantibodies bind to the thyrotropin receptor (TSHR) on the surface of thyroid follicular epithelial cells and stimulate thyroid growth and thyroid hormone synthesis and secretion via cyclic adenosine monophosphate (cAMP) production. The present study aimed to confirm the existence of TSHR in exosomes secreted from thyroid cells and to define the role of TSHR exosomes in GD.

Upregulation of calcitonin gene-related peptide, neuronal nitric oxide synthase, and phosphorylated extracellular signal-regulated kinase 1/2 in the trigeminal ganglion after bright light stimulation of the eye in rats.

Bright light stimulation of the eye activates trigeminal subnucleus caudalis (Vc) neurons in rats. Sensory information is conveyed to the Vc via the trigeminal ganglion (TG). Thus, it is likely that TG neurons respond to photic stimulation and are involved in photic hypersensitivity.

Monocyte and Basophil Counts as Predictors of Neutrophil Count Recovery in Patients with Thiamazole-Induced Agranulocytosis.

Thiamazole (MMI) is frequently used for the treatment of Graves' disease, but it occasionally induces agranulocytosis at the beginning of the treatment. To date, the predictive factors of recovery from MMI-induced agranulocytosis remain unclear. The primary aim of this study was to evaluate the predictive factor of the recovery time from MMI-induced agranulocytosis.

Cutoff value of thyroid uptake of (99m)Tc-pertechnetate to discriminate between Graves' disease and painless thyroiditis: a single center retrospective study.

Thyroid uptake of (99m)Tc-pertechnetate is a useful way to determine the cause of thyrotoxicosis. In daily clinical practice, (99m)Tc-pertechnetate uptake is used to discriminate between Graves' disease and painless thyroiditis when clinical information is not enough to make the distinction. However, since the optimal cutoff value of (99m)Tc-pertechnetate uptake has not yet been elucidated, our aim was to determine this value.

Amplification of the human epidermal growth factor receptor 2 gene in differentiated thyroid cancer correlates with telomere shortening.

The human epidermal growth factor receptor 2 (HER2) proto-oncogene plays an important role in the development and progression of breast and gastric cancer. Monitoring of the HER2 status and treatment with trastuzumab was performed initially in breast cancer, and subsequently in gastric cancer. However, the HER2 status of thyroid cancer remains unexplored.

Utilization of three-dimensional computed tomography for papillary thyroid carcinoma arising in the thyroglossal duct remnant: report of a case.

This report presents a rare and interesting case of papillary thyroid carcinoma arising in a thyroglossal duct remnant (TDR) that was diagnosed by three-dimensional computed tomography (3DCT). The patient, a 61-year-old woman, presented with a painless mass in the anterior suprahyoid region that had gradually enlarged over a 2-year period. Three-dimensional CT successfully revealed the thyroglossal duct (TD) descending from the tumor to the isthmus of the thyroid.

Follicular carcinoma arising from the pyramidal lobe of the thyroid.

We present a rare case of follicular carcinoma arising from the pyramidal lobe of the thyroid in a 21-year-old woman. Radical resection of the thyroid isthmus was performed, followed by adjuvant hormonal therapy with levothyroxine. After 15 months of follow-up, the patient remains disease-free.

Influence of interchanging self-etching primers and bonding agents on bond strengths to bovine dentin.

Purpose: To determine the influence of interchanging self-etching primers and bonding agents on dentin bond strengths.

Methods: Four commercially available self-etching primer dentin bond systems, Clearfil SE Bond (CB), Imperva Fluoro Bond (FB), Mac Bond II (MB), and Unifil Bond (UB) were used. Bovine mandibular incisors were mounted in self-curing resin and the facial dentin surfaces were ground wet on 600-grit SiC paper.

A case of Sheehan's syndrome with panhypopituitarism due to the impairment of both the hypothalamus and the pituitary.

Sheehan's syndrome is thought to be caused by pituitary necrosis associated with massive hemorrhage at delivery. We report here on a patient with Sheehan's syndrome, showing a rare type of panhypopituitarism suggesting dysfunction of both the hypothalamus and the pituitary. Although the basal level of plasma ACTH was normal, that of plasma cortisol was low.

Effect of self-etching primer application method on enamel bond strength.

Purpose: To determine the effect of self-etching primer application method on enamel bond strength.

Materials And Methods: Five commercial self-etching primer systems, Imperva Fluoro Bond, Mac Bond II, Clearfil Liner Bond II sigma, Clearfil SE Bond and Unifil Bond were used. Bovine mandibular incisors were mounted in self-curing resin and the facial enamel surfaces were ground wet on 600-grit SiC paper.

Analysis of the enamel/adhesive resin interface with laser Raman microscopy.

Adhesion of resin composites into enamel is currently believed to rely on infiltration of bonding resin into the porous zone, establishing micromechanical retention to etched enamel. This study investigated the change in chemical composition of the enamel/resin interface using a laser Raman microscopic system (System-2000, Renishaw). Two-step bonding systems, Mac Bond II (Tokuyama Corp), Clearfil Mega Bond and Single Bond (3M/ESPE) were employed.

Determination of residual double bonds in resin-dentin interface by Raman spectroscopy.

Objectives: The quality of the hybrid layer is believed to be more important than the thickness of this layer. The purpose of this study was to investigate a method to analyze the percentage of adhesive resin residual double bonds in the dentin-resin interface using laser Raman spectroscopy.

Methods: Bovine dentin was treated with dentin adhesives and resin composite was bonded according to the manufacturers' instructions.

Analysis of the dentin-resin interface by use of laser Raman spectroscopy.

Objectives: Adhesion of resin-bonding agents to dentin is currently believed to result from impregnation of adhesive resin into superficially demineralized dentin. The purpose of this study was to investigate the chemical composition of the resin-impregnated dentin (hybrid) layer using a micro-Raman spectroscopy.

Methods: Resin composites were bonded to bovine dentin with the two-step bonding systems, and specimens were sectioned parallel to dentinal tubules.

Use of an ultrasonic device for the determination of elastic modulus of dentin.

The mechanical properties of dentin substrate are one of the important factors in determining bond strength of dentin bonding systems. The purpose of this study was to determine the elastic modulus of dentin substrate with the use of an ultrasonic device. The dentin disks of about 1 mm thickness were obtaining from freshly extracted human third molars, and the dentin disk was shaped in a rectangular form with a line diamond point.

Influence of adhesive application duration on dentin bond strength of single-application bonding systems.

This study examined the relationship between the bond agent application duration and the dentin bond strength of several single-application bonding systems. The restorative material/ bonding systems used were Reactmer, with its single-application bonding system Reactmer Bond (RB, Shofu Inc, Kyoto, Japan); Palfique Estelite, with its single-application bonding system One-Up Bond F (OU, Tokuyama Co, Tokyo, Japan) and F2000 Compomer, with its bonding system Primer/Adhesive in Clicker (F2,3M Dental Products, St Paul, MN 55144, USA). Bovine mandibular incisors were mounted in self-curing resin and wet ground with #600 SiC to expose labial dentin.

Enamel and dentin bond strengths of single application bonding systems.

Purpose: To investigate the bonding ability to enamel and dentin of new single application bonding systems (Reactmer and One-Up Bond) and compare these with a commercial compomer (Clicker/F2000), and 2-step resin-based composite bonding systems (Fluoro Bond/Lite-Fil II A and Single Bond/Z100).

Materials And Methods: Labial surfaces of extracted bovine teeth were ground on wet 600-grit SiC paper to expose a flattened area of enamel or dentin and then washed and dried with oil-free compressed air. These surfaces were treated according to each adhesive system's instructions and the restorative materials were condensed into a Teflon mold (2 mm height, 4 mm internal diameter) and then irradiated.

Adhesion of single application bonding systems to bovine enamel and dentin.

Single application bonding systems have recently been developed in an effort to simplify and shorten bonding procedures. This study compared their bonding ability to enamel and dentin. Four commercial single application systems, Reactmer Bond (Shofu Inc), One-Up Bond F (Tokuyama Co), AQ Bond (Sun Medical Co, Japan) and Prompt L-Pop (ESPE, Germany) were used.

Effect of operator variability on dentin bond strength of two-step bonding systems.

Purpose: To examine the influence of operator variability on adhesion to dentin of recently developed two-step bonding systems.

Materials And Methods: A self-etching primer system, Fluoro Bond/Lite-Fil II A (FB) and a one-bottle adhesive system, Single Bond/Z100 (SB) were employed. Three groups, each consisting of 15 operators, were selected from the dentists at the university (Group 1), undergraduate students (Group 2), and general practitioners (Group 3).

Influence of environmental conditions on dentin bond strengths of recently developed dentin bonding systems.

A study was conducted to investigate the influence of temperature and relative humidity (RH) on the bond strengths of several recently developed dentin bonding systems. Six environmental conditions, (A) 25+/-0.5 degrees C, 50+/-5% RH, (B) 25+/-0.

Durability of enamel bond strength of simplified bonding systems.

The purpose of this study was to investigate the influence of thermal cycling on enamel bond strength of 2-step bonding systems. The systems used were self-etching primer systems; Imperva Fluoro Bond, Clearfil Liner Bond II, and Mac Bond II; and self-priming adhesive systems; One Step, OptiBond Solo, Prime & Bond 2.0, and Single Bond.

A subpopulation of fibroblast growth factor-2-binding heparan sulfate is lost in human papillary thyroid carcinomas.

We hypothesized that a change in composition of proteoglycans can regulate the bioactivity of fibroblast growth factor (FGF)-2 in the thyroid. In order to test this hypothesis, we established a simple and sensitive method for detecting FGF-2-binding heparan sulfates and characterized them in papillary thyroid carcinomas and normal thyroids. The thyroid extracts were applied to a Q-Sepharose anion exchange column.