Publications by authors named "Onoprienko E"

Changes of the stomach mucosa in retinol deficiency of the organism were studied by methods of scanning and transmission electron microscopy. Observation of stomach mucosa state of the animals was performed in dynamics (in proportion with increase of the vitamin deficiency). The disturbance of integrity of the apical part of the external cell membrane of the superficial epithelium and development of apical erosions in cells were established.

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Electron microscopic and morphometric methods were used to study the state of the parietal exocrinocytes of the proper glands of gastric mucosa in dynamics of A avitaminosis. The experiment was performed in 80 albino rats taken from mother's feeding with the initial body mass 40-50 g, divided into 2 groups. In animals of the first group A-avitaminosis was induced by feeding the animals with semisynthetic diet devoid of vitamin A.

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Morphofunctional analysis of the state of internal organs was made in rats which received varying amounts of mushroom powder. It has been established that the new product induces development of endovasculitis, dystrophy and lympho-histiocytic infiltrates of parenchymatous organs. The data obtained have evidenced the development of delayed allergic reactions to mushroom powder.

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Under conditions of experimental A-avitaminosis in cells of superficial epithelium of the chicken stomach mucous membrane certain ultrastructural changes of cytoplasmic membranes takes place. Amount of transport vesicles decreases, regeneration of membranes in the Golgi complex cisterns, secretory vesicles and apical part of the external cellular membrane with development of apical erosions is disturbed. The problem on influence of the changes mentioned to the process of mucus formation, in particular to protein glycosylation in the Golgi complex is discussed.

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It has been established that daily inclusion of modified Alaska pollack protein into the rat ration as a 10% substitute of casein does not induce any changes in the body. A long term (during 12 months) feeding of rats with the rations containing 50 and 100% of Alaska pollack protein, as casein substitute, results in significant changes in the histological structure of the kidneys and liver. The data of electron microscopy enabled the authors to make a conclusion on the presence of a toxic factor in the protein product studied.

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