Publications by authors named "Onofrio Sergio Saia"
Background: Retinopathy of prematurity (ROP) is a multifactorial disease with evidence of many associated risk factors. Erythropoietin has been reported to be associated with this disorder in a murine model, as well as in humans in some single-center reports. We reviewed the data from two large tertiary NICUs in Italy to test the hypothesis that the use of erythropoietin may be associated with the development of the most severe stages of ROP in extremely low birth weight (ELBW) neonates.
View Article and Find Full Text PDFArticle Synopsis
- Retinopathy of prematurity (ROP) is a common issue in premature infants, and this study investigates the effects of nutrition, specifically human maternal milk versus formula, on its development.
- The research analyzed data from two multicenter trials in Italy that focused on preventing infections in very low birth weight (VLBW) infants while also screening for ROP.
- The findings indicated that infants fed exclusively with maternal milk showed potential for reduced risk of developing ROP compared to those fed with preterm formula, although further analysis was required for confirmation.
Context: Sepsis is a common and severe complication in premature neonates, particularly those with very low birth weight (VLBW) (<1500 g). Whether lactoferrin, a mammalian milk glycoprotein involved in innate immune host defenses, can reduce the incidence of sepsis is unknown. In animal models, the probiotic Lactobacillus rhamnosus GG (LGG) enhances the activity of lactoferrin but has not been studied in human infants.
View Article and Find Full Text PDF