Patient outcomes after radiofrequency ablation stratified by Clinical, Etiology, Anatomy, and Pathophysiology classification.

Objective: Venous insufficiency is a prevalent and potentially debilitating disease. Treatment guidelines and techniques such as radiofrequency ablation (RFA) developed in the United States and Europe have been shown to provide significant improvements in quality of life; however, these have not been clearly assessed in the populations of developing nations. This study examined quality of life outcomes after RFA of patients treated at a single Jamaican vein center.

Determining glomerular filtration rate in homozygous sickle cell disease: utility of serum creatinine based estimating equations.

Background: Various estimating equations have been developed to estimate glomerular filtration rate (GFR) for use in clinical practice. However, the unique renal physiological and pathological processes that occur in sickle cell disease (SCD) may invalidate these estimates in this patient population. This study aims to compare GFR estimated using common existing GFR predictive equations to actual measured GFR in persons with homozygous SCD.

Neonatal outcomes of successful VBAC among obese and super-obese mothers.

Objective: We sought to evaluate neonatal morbidity and mortality among women who experienced successful vaginal births after previous cesarean delivery (VBAC) by obesity subtypes.

Methods: Missouri maternally linked cohort data files were utilized. Analyses were restricted to successful singleton VBACs.

Fetal sex and differential survival in preeclampsia and eclampsia.

Purpose: We investigate sex differences in the incidence of stillbirth, neonatal mortality, and perinatal mortality among singletons born to mothers with preeclampsia or eclampsia.

Methods: Retrospective cohort analysis of a population-based sample of singleton births covering the period 1989 through 2005 (n = 56,313).

Results: The study population comprised 26,931 female (47.

Impact of prenatal alcohol consumption on placenta-associated syndromes.

The biology of placental and fetal development suggests that alcohol may play a significant role in increasing the risk of feto-infant morbidity and mortality, but study results are inconsistent and the mechanism remains poorly defined. Previous studies have not examined the risk of placenta-associated syndromes (PASs: defined as the occurrence of either placental abruption, placenta previa, preeclampsia, small for gestational age, preterm, or stillbirth) as a unique entity. Therefore, we sought to examine the relationship between prenatal alcohol use and the risk of PAS among singleton births in the Missouri maternally linked data files covering the period 1989-2005.

Alcohol consumption during pregnancy and risk of placental abruption and placenta previa.

The purpose of this study was to examine the association between prenatal alcohol consumption and the occurrence of placental abruption and placenta previa in a population-based sample. We used linked birth data files to conduct a retrospective cohort study of singleton deliveries in the state of Missouri during the period 1989 through 2005 (n = 1,221,310). The main outcomes of interest were placenta previa, placental abruption and a composite outcome defined as the occurrence of either or both lesions.

Maternal alcohol use and medically indicated vs. spontaneous preterm birth outcomes: a population-based study.

Background: The aetiology of preterm birth remains poorly understood. The purpose of this study is to investigate if an association exists between prenatal alcohol consumption and preterm birth and to determine if such an association differs by subcategories of preterm birth.

Methods: We employed vital statistics data from the state of Missouri covering the period 1989-2005 (n = 1 221 677 singleton records).

Association between tobacco use in pregnancy and placenta-associated syndromes: a population-based study.

Introduction: Cigarette smoking is an established risk factor for adverse perinatal outcomes. The purpose of this study is to examine the association between maternal smoking in pregnancy and the occurrence of placental-associated syndromes (PAS).

Methods: We analyzed data from a population-based retrospective cohort of singleton deliveries that occurred in the state of Missouri from 1989 through 2005 (N = 1,224,133).

Intrauterine exposure to tobacco and risk of medically indicated and spontaneous preterm birth.

We investigated the association between prenatal smoking and the occurrence of medically indicated and spontaneous preterm delivery (<37 weeks). We performed a retrospective cohort study of singleton live births in the state of Missouri (n = 1,219,159) using maternally linked cohort data files covering the period 1989 to 2005. The main outcomes of interest were spontaneous and medically indicated preterm and very preterm birth.

The association of prepregnancy body mass index with pregnancy outcomes in triplet gestations.

The impact of obesity on triplet gestations is poorly understood. In this study, we investigate the association of obesity with birth outcomes in triplets. Triplet births in the state of Missouri from 1989 through 1997 were analyzed.

Maternal prepregnancy underweight and risk of early and late stillbirth in black and white gravidas.

Objective: The association between underweight and stillbirth remains poorly defined, especially across racial/ethnic sub-populations. We investigate the association of pre-pregnancy underweight on the risk for early and late stillbirth among black and white mothers.

Methods: We conducted analysis on the Missouri maternally linked data files covering the period 1989-1997 inclusive.

Extreme maternal underweight and feto-infant morbidity outcomes: a population-based study.

Objective: We sought to estimate the association between severity of maternal pre-pregnancy underweight and feto-infant morbidity outcomes.

Methods: Missouri maternally linked cohort records from 1989 to 1997 inclusive were analysed. Using pre-pregnancy maternal body mass index (BMI), we classified study participants into: Normal (18.

Maternal pre-gravid body weight and risk for placental abruption among twin pregnancies.

Objectives: Placental abruption is a major cause of fetal and neonatal death and has been reported more frequently in twin pregnancies than among singleton gestations. The purpose of this article is to investigate the role of maternal pre-gravid body mass index (BMI) on the risk for placental abruption among twin pregnancies.

Methods: We used the Missouri maternally linked cohort files (years 1989-1997) consisting of twin live births (gestational age 20-44 weeks).

Obesity subtypes and risk of spontaneous versus medically indicated preterm births in singletons and twins.

Using data from the Missouri maternally linked files (1989-1997), the authors examined the association among maternal obesity, obesity subtypes, and spontaneous and medically indicated preterm (<37 weeks) and very preterm (<33 weeks) births in singletons and twins. Adjusted odds ratios were obtained with correction for intracluster correlation. The prevalence of obesity increased by 77% over the study period (p(trend) < 0.