High molecular weight-neutrophil chemotactic activity in nasal allergy.

HMW-NCA is involved in the pathogenesis of nasal hypersensitivity reactions in humans. We, however, have little evidence about the role of neutrophils which migrate to the site of allergic reactions by HMW-NCA and other chemotactic mediators. This role of neutrophils in nasal hypersensitivity still remains to be clarified.

Release of high-molecular-weight neutrophil chemotactic activity from resected human nasal turbinate after antigen challenge.

Eleven patients with allergic rhinitis were studied. All subjects were sensitive to house dust mite documented by skin test, RAST score, and nasal provocation test. The patients needed lower turbinectomy because of chronic hypertrophic rhinitis.

Release of high molecular weight-neutrophil chemotactic activity from human tissues, cells and secretion.

Release of high molecular weight-neutrophil chemotactic activity from human tissues, cells and secretion was studied in vivo and in vitro. Lung, nasal turbinate, nasal polyps, skin of neurofibromatosis, basophils from chronic myeloid leukemia and cultured basophilic cells from cord blood released this mediator following calcium ionophore, antigen, anti-IgE or homogenization in vitro. Its release was also demonstrated in human nasal secretions from patients with allergic rhinitis following antigen challenge.

[Establishing guidlines for dealing with mild dysplasia through cytology and colposcopy (follow up study)].

230 cases of mild dysplasia, detected in examinations for cancer of the uterus, were followed up cytologically, and colposcopically for more than 2 and a maximum of 10 years, and the following results were obtained: Mild dysplasia resulted in regression in 169 cases (73.5%), persistence in 46 cases (20.0%), and progression in 15 cases (6.