Publications by authors named "Onanga Richard"

Article Synopsis
  • - The study investigates the prevalence of antibiotic-resistant extended-spectrum beta-lactamase (ESBL) in children under 5 suffering from diarrhea in public hospitals in Franceville, Gabon, an area lacking previous research on this topic.
  • - Researchers collected and analyzed 70 fecal samples from young children, identifying 26 strains of bacteria (33.0%) that produced ESBLs, with the majority carrying the bla gene.
  • - The findings reveal a high occurrence of ESBL-producing bacteria, primarily from phylogroup D, indicating potential issues related to the improper use of beta-lactam antibiotics among these children.
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Zoopharmacognosy is the study of the self-medication behaviors of non-human animals that use plant, animal or soil items as remedies. Recent studies have shown that some of the plants employed by animals may also be used for the same therapeutic purposes in humans. The aim of this study was to determine the antioxidant and antibacterial activity of Ceiba pentandra, Myrianthus arboreus, Ficus subspecies (ssp.

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Introduction: Infections caused by carbapenemase-producing Enterobacteriaceae (CPE) pose a significant threat, leading to severe morbidity and mortality among newborns.

Methods: This study, conducted at Franceville hospital's maternity and neonatology wards from February 22nd to June 20th, 2022, investigated the prevalence of CPE in 197 parturients and 203 newborns. Rectal swabs were taken from parturients before delivery and from newborns 30 minutes after birth.

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Background: In Central Africa, it is difficult to tackle antibiotic resistance, because of a lack of data and information on bacterial resistance, due to the low number of studies carried out in the field. To fill this gap, we carried out a systematic review of the various studies, and devised a molecular epidemiology of antimicrobial resistance from humans, animals and the environmental samples.

Method: A systematic search of all publications from 2005 to 2020 on bacterial resistance in Central Africa (Gabon, Cameroon, Democratic Republic of Congo, Central African Republic, Chad, Republic of Congo, Equatorial Guinea, São Tomé and Príncipe, Angola) was performed on Pubmed, Google scholar and African Journals Online (AJOL).

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Background: In Gabon, malaria remains a major public health problem. All malaria cases with axillary temperature ≥ 37.5°C with a parasites density ≥ 1200/μL are serious cases and must be treated as a medical emergency.

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Article Synopsis
  • Urinary tract infections (UTIs) are common in children and can lead to severe complications, particularly due to the emergence of antibiotic-resistant bacteria known as ESKAPE, which pose challenges for treatment.
  • A study conducted on 508 children in South-East Gabon found a high prevalence of UTIs (59%), primarily caused by E. coli and K. pneumoniae, with various resistance profiles complicating treatment options.
  • The research indicated that certain resistant strains, like DTR and CRE-E. coli, were linked to specific symptoms, highlighting the importance of understanding the antibiotic sensitivity of ESKAPE uropathogens for effective management of pediatric UTIs.
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Diarrheal diseases are a major cause of morbidity and mortality in infants and young children, particularly in sub-Saharan countries. In Gabon, there are few data on the prevalence of diarrheal pathogens in children. The aim of this study was to assess the prevalence of diarrheal pathogens in children with diarrhea in southeastern Gabon.

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Article Synopsis
  • * Findings revealed that 1.61% of clinical isolates and 5.26% of fecal samples were CP-GNB, with higher rates among inpatients (2.98%) and in intensive care units.
  • * The research identified Klebsiella pneumoniae and Acinetobacter baumannii as the most common CP-GNB, with blaOXA-48 being the most prevalent resistance gene, indicating a need for preventive measures to curb the spread of these resistant bacteria. *
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(1) Background: Terrestrial mammals in protected areas have been identified as a potential source of antimicrobial-resistant bacteria. Studies on antimicrobial resistance in gorillas have already been conducted. Thus, this study aimed to describe the phylogroups, pathotypes and prevalence of antimicrobial resistance of isolated from western lowland gorilla's faeces living in MDNP.

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Article Synopsis
  • * Researchers collected 174 samples from various livestock (chickens, swine, cattle, and sheep) and assessed their antibiotic susceptibility using specific lab techniques.
  • * Results indicated a very high prevalence of enterococci (>90% in all types of livestock) and significant resistance to multiple antibiotics, suggesting these animals may be key reservoirs of antibiotic resistance.
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Introduction: Discomfort in women of childbearing age associated with vaginal infections, namely bacterial vaginosis (BV), aerobic vaginitis (AV), vulvovaginal candidiasis (VVC), and trichomoniasis (TV), represent a serious and ongoing gynecological complication throughout the world.

Objective: This study aimed to investigate the etiologies of vaginal infections among outpatients in south-eastern Gabon.

Methodology: A cross-sectional study was designed using participants referred directly by their treating doctor for a vaginal swab.

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Background: Genital mycoplasma are only considered pathogenic at a certain level and are often associated with other pathological situations such as bacterial vaginosis (BV). They may lead to infertility as well as other gynaeco-obstetrical and neonatal problems. Despite numerous reported resistances, macrolides are required to treat pregnant women while non-pregnant women are managed with tetracyclines and fluoroquinolones.

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The emergence of antibiotic resistance is a major concern around the world. The objective of this study was to investigate the antibiotics used in livestock and their impact on resistance in and on farms in Gabon. A structured questionnaire was used to collect information on the farms.

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Article Synopsis
  • The study aimed to assess the prevalence of antibiotic resistance in Enterobacteriaceae from wild mammals in Gabon's national parks, focusing on both intrinsic and acquired resistance.
  • Researchers identified 90 enterobacterial isolates from 130 colonies, with Escherichia coli being the most common species (61%), followed by other species like Enterobacter cloacae and Proteus mirabilis.
  • Findings indicated that most resistant strains were wild type with intrinsic resistance, whereas acquired resistance was limited, particularly in E. coli (11%) and E. cloacae (3%).
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Article Synopsis
  • - The study examined the prevalence of extended-spectrum beta-lactamases-producing Enterobacteriaceae (ESBL-PE) in Gabon by analyzing nearly 6,000 clinical samples and anal swabs from various hospitals between January 2016 and March 2018.
  • - Findings revealed an ESBL-PE prevalence of 11.8% in clinical samples and 16.7% in anal swabs, with most isolates coming from urine, and the most common resistance genes identified were from the CTX-M group.
  • - Although the prevalence of ESBL-PE in Gabon is currently not alarming, the study emphasizes the need for corrective measures and ongoing monitoring to prevent their spread.
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The purpose of this study was to provide contextual information on indigenous food's technologies and safety from Gabon. The strategic focus being to promote local food with enhanced nutritional value and improved safety. An investigation and monitoring were carried out to elucidate their process flow diagrams and to identify safety failures.

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Article Synopsis
  • Urinary tract infections (UTIs) are a significant global health issue, leading to high rates of antibiotic use and consultations, especially in community settings.
  • The study aimed to investigate the prevalence and antibiotic resistance of specific uropathogenic strains in Franceville, conducting analysis on 1,086 urine samples over a 17-month period.
  • Results indicated a 29.2% prevalence of UTIs, predominantly affecting women, with notable resistance to certain antibiotics, emphasizing the importance of tailoring antibiotic usage based on local resistance patterns.
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Antibiotic resistance occurs in the environment by multiplication and the spread of multidrug-resistant bacteria that would be due to an improper and incorrect use of antibiotics in human and veterinary medicine. The aim of this study was to establish the prevalence of producing Extended-Spectrum beta-Lactamase (ESBL) antibiotics from rats and gregarious animals in a semirural area of Gabon and to evaluate the origin of a resistance distribution in the environment from animal feces. The bacterial culture was carried out, and the identification of strains on a specific medium and the antibiotic susceptibility tests allowed establishing the prevalence.

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In Gabon, terrestrial mammals of protected areas have been identified as a possible source of antibiotic-resistant bacteria. Some studies on antibiotic resistance in bats have already been carried out. The main goal of our study was to detect extended-spectrum beta-lactamases (ESBLs) that are produced by enterobacteria from bats in the Makokou region in Gabon.

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Gout is caused by a chronic hyperuricemia whose complications are not currently well evaluated in Africa. The aim of this study was to determine the prevalence and risk factors of hyperuricemia and gout in 85 patients recruited. A total of 26 cases of hyperuricemia, i.

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The majority of patients with acute febrile jaundice (>95%) identified through a yellow fever surveillance program in the Democratic Republic of Congo (DRC) test negative for antibodies against yellow fever virus. However, no etiological investigation has ever been carried out on these patients. Here, we tested for hepatitis A (HAV), hepatitis B (HBV), hepatitis C (HCV), hepatitis D (HDV), and hepatitis E (HEV) viruses, all of which can cause acute febrile jaundice, in patients included in the yellow fever surveillance program in the DRC.

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Wild animal meat represents an important source of protein for many people in central Africa. Also known as bushmeat, this meat commodity is derived from wild animals hunted under uncontrolled conditions, transported to distant markets under rudimentary or no hygienic methods, and often eviscerated >24 hr after death. Considering the plausible role of wildlife as a reservoir for bacterial zoonotic pathogens, bushmeat may be an important public health risk in Central Africa.

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