Publications by authors named "Onal C"
Background: Tumor suppressors are well known drivers of cancer invasion and metastasis in metastatic castration sensitive prostate cancer (mCSPC). However, oncogenes are also known to be altered in this state, however the frequency and prognosis of these alterations are unclear. Thus, we aimed to study the spectrum of oncogene mutations in mCSPC and study the significance of these alteration on outcomes.
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- This study explored the use of diffusion-weighted MRI to evaluate prostate cancer patients with Gleason score 7 tumors before radiotherapy, focusing on the correlation between MRI results, cancer characteristics, and treatment outcomes.
- It was found that tumors classified as GS 3+4 had higher ADC values compared to GS 4+3 tumors, indicating a difference in disease aggression, with lower ADC values linked to poorer survival rates.
- The research concluded that ADC values could serve as an effective biomarker to distinguish between different types of GS 7 tumors, with lower values correlating with a higher risk of disease progression and worse long-term outcomes.
Article Synopsis
- - There is a need for better tools to help manage oligometastatic castration-sensitive prostate cancer (omCSPC), as highlighted in a retrospective study examining the effectiveness of the ArteraAI Prostate Test.
- - This study involved 222 men and measured outcomes like overall survival (OS) and time until the cancer becomes castration-resistant, finding a high MMAI score linked to worse OS and shorter time to resistance.
- - Additionally, the study indicated that patients with high MMAI scores who received metastasis-directed therapy (MDT) had improved metastasis-free survival compared to those with low scores, pointing to the potential of the MMAI biomarker for guiding treatment decisions.
Article Synopsis
- The study evaluated the outcomes of younger (< 70 years) and older (≥ 70 years) prostate cancer patients after receiving definitive radiotherapy, focusing on disease-free survival and side effects.
- Findings showed similar 7-year biochemical disease-free survival and prostate cancer-specific survival rates between the two age groups, despite older patients having additional risk factors and comorbidities.
- The research concluded that definitive radiotherapy is a safe and effective treatment for localized prostate cancer regardless of age, as older patients experience comparable rates of survival and toxicity to younger ones.
Objective: This study compared the efficacy of ultrasound-guided erector spinae plane block (ESPB) and wound infiltration (WI) for postoperative analgesia in patients who underwent lumbar spinal surgery with instrumentation.
Methods: In this randomized controlled trial, 80 patients were divided into two groups: ESPB (n = 40) and WI (n = 40). Postoperative pain intensity was assessed via the visual analog scale (VAS) at multiple time points within 24 h.
The primary objective of this in vitro study was to prevent the risk of toxicity associated with bupivacaine, widely used in clinical practice, by using magnesium (Mg), a readily available and cost-effective element, as an adjuvant. We hypothesized that Mg might exhibit a protective effect against cytotoxicity in a colon cell culture model under conditions of bupivacaine-induced LAST. Our secondary aim was to investigate its effect on genotoxicity, apoptosis, and iROS.
View Article and Find Full Text PDFBackground: We analyzed a dose escalation of 36.25 Gy to the entire prostate and a dose increment up to 40 Gy with 1.25 Gy increments to intraprostatic lesion (IPL) using simultaneous integrated boost (SIB) in five fractions.
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- The study aimed to evaluate the effectiveness of stereotactic body radiotherapy (SBRT) on patients with oligometastatic colorectal cancer (CRC) and its impact on survival and local control rates.
- A total of 388 patients with up to 5 metastatic lesions were analyzed, showing that most had previously undergone surgery and had limited organ involvement, with median follow-up of about 30.7 months.
- Results indicated that higher SBRT doses (≥100 Gy) significantly improved local control, progression-free survival, and overall survival rates, highlighting SBRT as a promising treatment for metastatic CRC.
Purpose: To assess the early metabolic response of the primary tumor using Gallium-68 (Ga)-labeled-prostate-specific membrane antigen positron emission tomography (Ga-PSMA-PET/CT), as well as the relationship between PSMA change in the primary tumor and PSA response after definitive radiotherapy (RT), either alone or in combination with androgen deprivation therapy (ADT) in intermediate risk prostate cancer (IR-PCa) patients.
Methods: The clinical data of 71 IR-PCa patients treated with RT alone (36 patients, 50.7%) or RT and ADT (35 patients, 49.
Purpose: This study sought to determine the predictive and prognostic value of clinicopathological parameters and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and hemoglobin (Hgb) level in predicting recurrence patterns and locoregional relapse-free survival (LRFS) and distant metastasis-free survival (DMFS) in cervical cancer patients receiving definitive chemoradiotherapy (ChRT).
Methods: This study included 261 cervical cancer patients treated with ChRT. The primary endpoints were the predictors of local recurrence (LR) and distant metastasis (DM), whereas the secondary endpoints were LRFS and DMFS.
Purpose: This study investigated imaging biomarkers derived from PSMA-PET acquired pre- and post-metastasis-directed therapy (MDT) to predict 2-year metastasis-free survival (MFS), which provides valuable early response assessment to improve patient outcomes.
Materials/methods: An international cohort of 117 oligometastatic castration-sensitive prostate cancer (omCSPC) patients, comprising 34 from John Hopkins Hospital (JHH) and 83 from Baskent University (BU), were treated with stereotactic ablative radiation therapy (SABR) MDT with both pre- and post-MDT PSMA-PET/CT scans acquired. PET radiomic features were analyzed from a CT-PET fusion defined gross tumor volume ((GTV) or zone 1), and a 5 mm expansion ring area outside the GTV (zone 2).
Article Synopsis
- This study explores how toxoplasmosis might influence epilepsy by examining the HMGB1/RAGE/TLR4/NF-κB signaling pathway in patients with idiopathic epilepsy.
- The research involves four groups based on the presence of epilepsy and Toxoplasma gondii (T. gondii) antibodies, analyzing differences in gene expression related to inflammation and signaling pathways.
- Results indicate that specific gene expressions are significantly higher in epilepsy patients with or without toxoplasmosis, suggesting a link between the immune response and seizure mechanisms.
Background: Alterations in the PIK3/Akt/mTOR pathway are commonly seen in metastatic castration-sensitive prostate cancer (mCSPC), however their role in outcomes is unknown. We aim to evaluate the prognostic significance as well as the genetic landscape of PIK3/Akt/mTOR pathway alteration in mCSPC.
Methods: Fourhundred and seventy-two patients with mCSPC were included who underwent next generation sequencing.
Article Synopsis
- Oligometastatic castration-sensitive prostate cancer (omCSPC) is an early stage of metastatic disease with varying outcomes among patients, leading to a study on the impact of tumor genomics on disease progression and failure patterns after treatment.
- A multi-institutional analysis of 267 men who underwent tumor sequencing highlighted that the presence of specific genomic mutations, like TP53, could influence modes of progression and overall survival rates.
- The findings suggested that patients with oligoprogression had significantly better three-year overall survival rates (91%) compared to those with polyprogression (71%), indicating the importance of genomic profiling in predicting clinical outcomes.
Article Synopsis
- The study examined the effectiveness of PSMA PET/CT imaging compared to traditional imaging methods in treatment outcomes for patients with node-positive prostate cancer who received androgen deprivation therapy (ADT) and external radiotherapy (RT).
- Results showed that patients assessed with PSMA PET/CT had significantly higher 5-year prostate cancer-specific survival rates (95.1%) compared to those who underwent conventional imaging (76.9%).
- Findings suggested that factors such as the duration of ADT and post-RT PSA levels were crucial in predicting both progression-free survival and survival specific to prostate cancer, indicating that PSMA PET/CT provides better prognostic information for patient outcomes.
Purpose: Emerging data suggest that metastasis-directed therapy (MDT) improves outcomes in patients with oligometastatic castration-sensitive prostate cancer (omCSPC). Prostate-specific membrane antigen positron emission tomography (PSMA-PET) can detect occult metastatic disease, and PSMA response has been proposed as a biomarker for treatment response. Herein, we identify and validate a PSMA-PET biomarker for metastasis-free survival (MFS) following MDT in omCSPC.
View Article and Find Full Text PDFBackground/aim: To compare implant sparing irradiation with conventional radiotherapy (RT) using helical (H) and TomoDirect (TD) techniques in breast cancer patients undergoing immediate breast reconstruction (IBR).
Patients And Methods: The dosimetric parameters of 40 patients with retropectoral implants receiving 50.4 Gy delivered in 28 fractions were analyzed.
Purpose: To compare the biochemical failure (FFBF) and prostate cancer specific survival (PCSS) rates of patients with intermediate-risk prostate cancer (IR-PC) who were treated with 6 months of androgen deprivation therapy (ADT) with 78 Gy to the prostate, those treated with ADT and focal boost (FB) of 86 Gy to intraprostatic lesion (IPL) using the simultaneous-integrated boost (SIB) technique, and those treated with SIB alone.
Materials And Methods: A retrospective analysis of 320 IR-PC patients treated between January 2012 and April 2021 was performed. Patients were divided into three groups based on their treatment arm: 78 + ADT (109 patients, 34.
For transradial amputees, robotic prosthetic hands promise to regain the capability to perform daily living activities. Current control methods based on physiological signals such as electromyography (EMG) are prone to yielding poor inference outcomes due to motion artifacts, muscle fatigue, and many more. Vision sensors are a major source of information about the environment state and can play a vital role in inferring feasible and intended gestures.
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