Sulfur traits in the plant microbiome: implications for sustainable agriculture.

Owing to its biochemical flexibility, sulfur (S) is uniquely poised to fulfill versatile roles in plant-microbe interactions - impacting their metabolism with significant consequences for plant health and the global S cycle. We present evidence that the diversity of S-metabolic genes in plant-associated microbiomes (phytobiomes) is underappreciated, and plant niches are hotspots of bacterial S-metabolism with implications for S emissions. Building upon emerging findings, we posit that coordination of S-metabolism between plants and phytobiomes is a common mechanism for plant-microbe homeostasis and agriculturally beneficial microbial services.

Deep-Learning-Assisted Understanding of the Self-Assembly of Miktoarm Star Block Copolymers.

The self-assemblies of topological complex block copolymers, especially the AB type miktoarm star ones, are fascinating topics in the soft matter field, which represent typical self-assembly behaviors analogous to those of biological membranes. However, their diverse topological asymmetries and versatile spontaneous curvatures result in rather complex phase separations that deviate significantly from the common mechanisms. Thus, numerous trial-and-error experiments with tremendous parameter space and intricate relationships are needed to study their assemblies.

Cell-free supernatant of Clostridium leptum inhibits breast cancer cell proliferation.

Breast cancer has emerged as the leading cause of global cancer incidence, surpassing lung cancer. Accumulating evidence suggests that probiotics exhibit inhibitory effect on breast cancer progression, highlighting the need to identify gut flora-derived probiotics with potential anti-breast cancer properties. Here, we investigated the effect of the cell-free supernatant of C.

Flexible microcolumn array-based silk fibroin for sweat glucose monitoring.

Flexible sweat sensors possess the special potential for continuous non-invasive monitoring of human blood glucose. We put forward a flexible microcolumn array sensor, which is designed for health monitoring by means of detecting glucose levels in sweat and capturing physiological signals related to human movement. With the combination of silk fibroin (SF), waterborne polyurethane (PU), and multi-walled carbon nanotubes (MWCNT), this microcolumn film electrode is able to effectively function as a strain sensor benefiting from the superior mechanical performance of PU.

Recanalization for Symptomatic Non-acute Intracranial Large Vessel Occlusion: An Observational Study.

Aim: This study investigated the efficacy and safety of endovascular revascularization for symptomatic non-acute atherosclerotic intracranial LVO.

Methods: For non-acute atherosclerotic intracranial large vessel occlusion (LVO), despite aggressive medical treatment, recurrent ischemic stroke or transient ischemic attack related to the occluded artery still occurs repeatedly. This retrospective cohort study included stroke patients with intracranial LVO who received endovascular treatment (EVT), categorized by successful recanalization and the time interval from symptom onset to revascularization (＜30 days vs.

Gamma Ray-induced Mutations in pyrEF Genes in Frankia casuarinae Strain CcI3.

Frankia spp. are multicellular actinobacteria with the ability to fix atmospheric dinitrogen (N). Frankia fixes N not only in the free-living state, but also in root-nodule symbioses with more than 200 plant species called actinorhizal plants.

Effect of Perioperative Immunonutrition on Outcomes in Gastric Cancer Surgery Patients: A Systematic Review and Evidence Map.

Background: Tumors and surgical procedures trigger a series of metabolic responses that put gastric cancer patients at constant risk of malnutrition during the perioperative period. Meanwhile, the effectiveness of enteral immunonutrition (EIN) for these patients remains a subject of ongoing debate.

Objective: This systematic review and evidence map aim to retrieve randomized controlled trials (RCTs) on perioperative EIN interventions in gastric cancer patients undergoing surgery and evaluate their effectiveness.

Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered liver lipid metabolism on a ketogenic diet.

Acetyl-CoA Synthetase Short Chain Family Member-1 (ACSS1) catalyzes the ligation of acetate and coenzyme A to generate acetyl-CoA in the mitochondria to produce ATP through the tricarboxylic acid (TCA) cycle. We recently generated an ACSS1-acetylation (Ac) mimic knock-in mouse, where lysine 635 was mutated to glutamine (K635Q), which structurally and biochemically mimics an acetylated lysine. ACSS1 enzymatic activity is regulated, at least in part, through the acetylation of lysine 635 in mice (lysine 642 in humans), a Sirtuin 3 deacetylation target.

Galectin-3 activates microglia and promotes neurological impairment via NLRP3/pyroptosis pathway following traumatic brain injury.

Background: Externally caused traumatic brain injury (TBI) poses a woeful worldwide health concern, bringing about disability, death, and prolonged neurological impairment. Increased galectin-3 levels have been linked to unfavorable outcomes in several neurological conditions. This study explores the role of galectin-3 in TBI, specifically examining its contribution to neuroinflammation.

Research progress in the extraction, purification, structural features, biological activities, and structure-activity relationships from Prunella vulgaris polysaccharides.

Prunella vulgaris L., a globally recognized medicinal and edible plant, has been extensively used in China for over 2000 years, possessing the efficacy of clearing liver-fire, brightening the eyes, dispersing the knot, and reducing swelling. Phytochemical studies have shown that Prunella vulgaris contains various biologically active compounds, including flavonoids, triterpenes, polysaccharides, and phenolic acids.

Enhanced mitochondrial biogenesis facilitates the development of cutaneous squamous cell carcinoma.

Mitochondrial malfunction is traditionally viewed as a major factor in tumor growth and malignancy, while recent studies have introduced conflicting views suggesting the necessity of functional mitochondria for tumor growth. Despite these differing perspectives, the specific role of mitochondria in cutaneous squamous cell carcinoma (cSCC) remains poorly understood. In this study, we observed increased mitochondrial abundance and function during the development of cSCC.

Characterization of Klebsiella pneumoniae Carbapenemase (KPC)-14, a KPC Variant Conferring Resistance to Ceftazidime-Avibactam in the Extensively Drug-resistant ST463 Pseudomonas aeruginosa Clinical Isolate.

Objectives: We studied two Klebsiella pneumoniae carbapenemase (KPC)-14 variants from clinical Pseudomonas aeruginosa isolates (C137 and C159) to better understand the genomic diversity, mechanisms, and genes that confer antibiotic resistance and pathogenicity.

Methods: Genomic DNA from C137/159 was subjected to Illumina and Oxford Nanopore sequencing. Horizontal transmission of the plasmid was evaluated using cloning experiments.

Older Adults with Diabetes in Korea: Latest Clinical and Epidemiologic Trends.

Backgruound: Diabetes in older adults is becoming a significant public burden to South Korea. However, a comprehensive understanding of epidemiologic trends and the detailed clinical characteristics of older adults with diabetes is lacking. Therefore, we evaluated epidemiologic trends and the metabolic and lifestyle characteristics of diabetes in Korean older adults.

TRIM8 enhances chondrocyte ferroptosis by inhibiting YTHDF2-m6A mediated SREBF2 mRNA degradation to promote OA progression.

Chondrocyte ferroptosis plays a crucial role in osteoarthritis (OA) progression. Our previous study demonstrated that TRIM8 knockdown alleviated IL-1β-induced chondrocyte injury. However, the involvement of TRIM8 in regulating OA progression through ferroptosis remains unclear.

Effects of the triglyceride-glucose index on non-alcoholic fatty liver disease: Causal evidence from longitudinal cohort studies.

Background: Insulin resistance (IR) is strongly related to non-alcoholic fatty liver disease (NAFLD). Triglyceride-glucose (TyG) index serves as a novel substitute indicator for IR. However, research on the effect of TyG index on NAFLD remains sparse.

Enhanced π-conjugation in hybridized local and charge transfer emitters for efficient red OLEDs and bioimaging.

Red-emitting materials have significantly advanced the development of materials for OLEDs and bioimaging. However, traditional red dyes often suffer from the 5 % external quantum efficiency (EQE) limit and aggregation-caused quenching (ACQ), which impede their practical applications. Herein, two red-emitting materials, TPA-QP and Cz-Ph-QP were designed and synthesized with donor-acceptor (D-A) structures.

LncRNA A2ml2 inhibits fatty liver hemorrhage syndrome progression and function as ceRNA to target LPL by sponging miR-143-5p.

Fatty liver hemorrhage syndrome (FLHS) is the most common metabolic diseases in laying hens during the late-laying period, and it causes a significant economic burden on the poultry industry. The competing endogenous RNA plays crucial roles in the occurrence and development of fatty liver. Based on the previously constructed lncRNA-miRNA-mRNA networks, we selected the axis of ENSGALT00000079786-LPL-miR-143-5p for further study to elucidate its mechanistic role in development of fatty liver.

Construction of hierarchical nanostructured surface on an organic hybrid selenidostannate with light trapping effect to achieve sunlight-driven environmental remediation.

Due to the low intensity of sunlight, it is a great challenge to realize highly efficient sunlight-driven photocatalysis. To maximize the utilization of sunlight, increasing the light capturing ability of photocatalysts is a prerequisite to attain high catalytic performances. Due to the multiple reflections of light in the hierarchical nanostructures, constructing hierarchical nanostructured surface should boost the sunlight capturing ability of a photocatalyst.

Effects of exogenous mineral silicon on physiological characteristics and arsenic uptake and transport in rice.

Soil arsenic (As) contamination poses a significant threat to food security and human health. Diatomaceous earth (DE) as a representative exogenous mineral silicon can effectively regulate the migration and transformation of As in the soil-rice system. However, the mechanisms underlying the effects of DE application on As uptake, translocation, and stress regulation in rice remain unclear.

FeMo integrated covalent organic frameworks: Peroxidase-mimetic colorimetric biosensors for multivariate sensing hydrogen peroxide and ascorbic acid in serum and beverages.

An efficient and readable sensor is desirable for food safety and diagnosis. Herein, a homogeneous mimicking enzyme was constructed by encapsulating polyoxometalate (NH₄)₃[FeMo₆O₁₈(OH)₆]·6H₂O (FeMo) into the covalent organic framework (FeMo@COF). Coordinating the spatial confinement effect of COF, FeMo exhibited superior peroxide-like activity to catalyze HO to O• which achieved the "on-off" consecutive sensing of HO and AA via a readable colorimetric mode, with the limit of detection (LOD) at 30 μM and 0.

Defect-induced persistent photoconductivity and nonvolatility in two-dimensional BiSe thin film for neuromorphic vision sensing capability.

Optical synaptic devices (OSDs) have neuromorphic vision sensing capability showing great potential in breaking the von Neumann bottleneck and facilitating future artificial vision systems. However, the applications of two-dimensional (2D) material-based OSDs are still impeded by complicated structures, preparation techniques and so on. In this work, we propose a 2D OSD based on BiSe films prepared by a chemical vapor deposition method followed by an in-situ thermal treatment.

The discovery of novel antimicrobial peptides against drug-resistant bacteria based on fragments fusion strategy.

Since the escalating prevalence of multidrug-resistant (MDR) bacterial infections posing global health challenges, novel antimicrobial agents are urgently needed. This study designed a series of antimicrobial peptides by fusing two fragments of antimicrobial peptides sC18 (1-9) and MSI-78 (10-16). Among these peptides, 13DKDab exhibited broad-spectrum antimicrobial efficacy against six different MDR bacterial strains with relatively low MICs.

Underrated risk of antibiotic resistance genes dissemination mediated by bioaerosols released from anaerobic biological wastewater treatment system.

Antibiotic resistance has been recognized as one of the most prevalent public health problems. The bioaerosol-mediated spread of antibiotic resistance genes (ARGs) is an important but underrated pathway. Therefore, this work investigated the comprehensive resistome and pathogen-induced risk in bioaerosols released from anaerobic ammonium oxidation (anammox) process under antibiotic stress.

A review-based estimation of GHG emissions of China's wastewater management system.

Under China's "Dual Carbon Goal", the wastewater treatment system plays a crucial role in the country's efforts to reduce greenhouse gas (GHG) emissions. However, a lack of baseline emissions data poses challenges for decarbonization efforts. This study aims to profile and diagnose the GHG emissions of China's entire wastewater system and identify key contributing factors.