Publications by authors named "Omotosho Dhulqarnain Akanji"
Objective: Osteocalcin (OCN) influences spermatogenesis in conjunction with testosterone and estrogen. OCN facilitates the secretion of testosterone by engaging with G protein-coupled receptor class C group 6 member A (GPRC6A) on Leydig cells and with androgen receptors on Sertoli cells.
Methods: Adult mice were assigned to the following groups: control; sham I, which received dimethyl sulfoxide for 5 weeks followed by phosphate-buffered saline for 1 month; azoospermia, which was treated with busulfan (40 mg/kg); sham II, which consisted of azoospermic animals that received phosphate-buffered saline for 1 month beginning at the 5-week mark; and the experimental group, which included azoospermic mice treated with OCN (3 ng/g/day) for 1 month.
Pentoxifylline promotes spermatogenesis via upregulation of the Nrf2-ARE signalling pathway in a mouse model of germ-cell apoptosis induced by testicular torsion-detorsion.
Reprod Fertil Dev
April 2023
Article Synopsis
- The study investigates the protective effects of pentoxifylline on germ cell survival after testicular torsion-detorsion in male mice.
- Histological analysis showed that pentoxifylline treatment resulted in healthier testicular structures and lower apoptotic cell rates compared to untreated groups.
- The findings suggest that pentoxifylline could be an effective adjunct therapy to surgery for preventing infertility caused by testicular torsion.