In Silico Structural Insights into a Glucanase from Clostridium perfringens and Prediction of Structural Stability Improvement Through Hydrophobic Interaction Network and Aromatic Interaction.

Glucanases are widely applied in industrial applications such as brewing, biomass conversion, food, and animal feed. Glucanases catalyze the hydrolysis of glucan to produce the sugar hemiacetal through hydrolytic cleavage of glycosidic bonds. Current study aimed to investigate structural insights of a glucanase from Clostridium perfringens through blind molecular docking, site-specific molecular docking, molecular dynamics (MD) simulation, and binding energy calculation.

Biosynthesis of nanoparticles using microorganisms: A focus on endophytic fungi.

The concept of this review underscores a significant shift towards sustainable agricultural practices, particularly from the view point of microbial biotechnology and nanotechnology. The global food insecurity that causes increasing ecological imbalances is exacerbating food insecurity, and this has necessitated eco-friendly agricultural innovations. The chemical fertilizers usage aims at boosting crop yields, but with negative environmental impact, thus pushing for alternatives.

Therapeutic Decisions and Implications in Patients With Attention Deficit Hyperactivity Disorder Versus Bipolar Disorder: Key Insights for Clinicians.

Attention deficit hyperactivity disorder (ADHD) and pediatric bipolar disorder (BD) are conditions that often manifest in childhood and can persist into adulthood. Due to the similarities in their clinical presentations, it is crucial for clinicians to have a thorough understanding of these disorders. Accurate differentiation of symptoms is essential for making precise diagnoses, as this directly influences treatment decisions and affects the overall functioning and quality of life of those impacted.

Dataset on MatK-based intra- and inter-specific genetic relationships among four L. species from Southwestern Nigeria.

Globally, the eggplant clade ( L.) (Solanaceae) is an economically important source of food, nutrition, income, and medicines. Members of the clade are distinctively known for their incompatibility and yet genetically related as a diploid hyper-diverse monophyletic group.

A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders.

Background: The treatment of diverse diseases using plant-derived products is actively encouraged. In the past few years, cannabidiol (CBD) has emerged as a potent cannabis-derived drug capable of managing various debilitating neurological infections, diseases, and their associated complications. CBD has demonstrated anti-inflammatory and curative effects in neuropathological conditions, and it exhibits therapeutic, apoptotic, anxiolytic, and neuroprotective properties.

Corrigendum: of maize plant: Potentials of propitious phytomicrobiome as biocontrol agents.

[This corrects the article DOI: 10.3389/ffunb.2023.

of maize plant: Potentials of propitious phytomicrobiome as biocontrol agents.

Disease outbreaks have been recorded due to exposure to  and fumonisin, a mycotoxin produced by this fungus. is a fungal pathogen of maize that causes infections, such as wilting and rotting, while contact with its fumonisin derivative manifests in the form of mild to severe illnesses in humans and animals. Maize infection by  causes loss or reduction in expected crop yield, thereby influencing households and nations' economies.

FEEDING PRACTICES AND NUTRITIONAL STATUS OF UNDER-FIVE CHILDREN IN A PERI-URBAN SETTING IN IBADAN, SOUTHWEST NIGERIA: A COMPARATIVE CROSS-SECTIONAL STUDY.

Background: Existing literature suggests inequalities in nutritional and feeding practices for children in rural communities compared to their urban counterparts. However, with increasing urbanization and changing social norms, re-assessment of rural-urban differences in feeding practices for under-five children is essential. This study therefore aimed to assess the feeding practices and nutritional status of children in a peri-urban setting in Ibadan.

Perception and predictors of spousal involvement in antenatal care by women attending immunization clinic at babcock university teaching hospital, Ogun State, Nigeria.

Background: The level of spousal involvement in antenatal care (ANC) is not what it should be. This is a concern because a number of preventable maternal and neonatal mortality or morbidity can be attributed to a lack of interest or participation in ANC by their spouses, which usually result in a delay in seeking healthcare and/or delay in reaching a healthcare facility.

Aim: To assess the degree of spousal involvement in ANC among women accessing care at the Immunization Clinic in Babcock University Teaching Hospital (BUTH), Ogun State, Nigeria.

'Prospective audit with intervention and feedback' as a core antimicrobial stewardship strategy in the paediatrics department of a Nigerian tertiary hospital.

Introduction: Inappropriate use of antibiotics for childhood illnesses, especially for non-bacterial infections, contributes to the development of antimicrobial resistance (AMR). Globally, implementation of antimicrobial stewardship programme (ASP) in all healthcare institutions is a strategic intervention to improve the appropriate use of antibiotics, reduce antimicrobial consumption and tackle AMR. The aim of this study was to evaluate the effect of prospective audit with intervention and feedback as an antimicrobial stewardship strategy on antimicrobial use, evaluate prescribers' response to recommendations and determine the rate of AMR in the Paediatrics Department of the Lagos University Teaching Hospital, Nigeria.

In silico molecular modeling and simulations of black tea theaflavins revealed theaflavin-3'-gallate as putative liver X receptor-beta agonist.

The low constitutive activation of Liver X receptor, an endogenous nuclear receptor with two subtypes (α and β), is a condition lying at the crossroad of cancer and cardiovascular disease. Both natural and synthetic Liver X receptor agonists have reportedly shown remarkable antiproliferative and atheroprotective effects but the repeated doses of its synthetic ones are also paradoxically associated with hyperlipidaemic effects and neurotoxicity, though attributed to the alpha subtype. This highlights the need for novel, safe, and potent LXR-beta-selective agonists.

Survey of Maize Rhizosphere Microbiome Using Shotgun Metagenomics.

Several processes which occur in the rhizosphere make it a vital region in plant development. However, studies that examine rhizosphere microbiomes and their functional potentials remain scarce. Shotgun metagenomics was employed here to evaluate the functional potentials of the maize rhizosphere microbiome of farms in two South African provinces.

Dataset on the toxic effects of aflatoxin and ochratoxin a on the human gastric smooth muscle cells.

This dataset determined the effects of aflatoxins (B, B, G and G) and Ochratoxin A extracted from ginger collected purposively from different retails in Mafikeng, North West province of South Africa, on the Human Gastric Smooth Muscle Cells. Hundred samples of ginger were collected and utilized for this purpose and the above mentioned toxins were extracted from the ginger, screened for on ELISA, quantified by HPLC and were exposed to the cells both individually and in combination (i.e aflatoxin and ochratoxin were combined) at different concentrations (high, moderate and low) using the human interferon beta kit.

Comparative study of aflatoxin contamination of winter and summer ginger from the North West Province of South Africa.

The presence of mycotoxins in staple food can have adverse effect that result in ill health and associated socio-economic losses. Mycotoxins are naturally occurring toxins produced by certain fungi and can be found in staple food plants such as ginger. Ginger is a renowned medicinal plant that is extensively used for cooking and healing.

Prevalence of Mycotoxins and Their Consequences on Human Health.

Mycotoxin contamination is a global phenomenon and causes a wide array of negative effects and other complications. This study focused on commonly found mycotoxins in Africa and the possible means of prevention or reduction of their contaminating effects. Mycotoxins are secondary metabolites of mold and fungi; they are generally toxic to living organisms.