Publications by authors named "Omori Taku"
Background: The effects of myocarditis after mRNA COVID-19 vaccination (mCV) on myocardial tissue, and the association between cardiomyocyte injury and clinical presentation, are not fully understood.
Methods And Results: We retrospectively registered patients clinically diagnosed with myocarditis after the first or second mCV who underwent endomyocardial biopsy or autopsy from 42 participating centers in Japan. We investigated the histological features and their association with clinical presentation based on cardiomyocyte injury.
Article Synopsis
- The study aimed to see if cardiovascular magnetic resonance radiomics can differentiate between noncollagen and inflammatory extracellular space from collagen in patients with dilated cardiomyopathy.
- Researchers analyzed data from 132 patients who had undergone heart imaging and a biopsy, calculating various radiomic features and using principal component analysis to narrow them down for better diagnostic accuracy.
- Results showed four distinct histopathological groups, revealing that noncollagenous extracellular space expansion had the strongest link to myocardial inflammation, and using radiomics improved the differentiation between types of extracellular space compared to traditional imaging methods.
Multidetector computed tomography (MDCT) can provide valuable information for mitral assessment, but its role in transcatheter mitral edge-to-edge repair (TEER) planning has been poorly elucidated. We aimed to compare MDCT with 3-dimensional transesophageal echocardiography (3D-TEE) for TEER preprocedural evaluation. We analyzed the preprocedural MDCT and 3D-TEE of 108 consecutive patients with mitral regurgitation (MR) who underwent MitraClip implantation.
View Article and Find Full Text PDFBackground: Little is known about how tightly right atrial pressure (RAP) is associated with prognosis in patients with severe tricuspid regurgitation (TR). The aim of this study was to investigate the association of RAP estimated by echocardiography (RAP-echo) with cardiovascular events in patients with severe TR.
Methods: Two hundred forty outpatients (median age, 75 years; 130 women) who underwent two-dimensional transthoracic echocardiography and were diagnosed with severe TR were retrospectively studied.
Article Synopsis
- The study categorizes mitral stenosis (MS) into three causes: rheumatic MS, degenerative MS, and post-clip MS, but the clinical differences between them were unclear.
- A review of 293 patients showed no significant differences in mitral valve orifice area, but those with post-clip MS had lower pressure gradients.
- Patients with rheumatic MS experienced more dyspnea, and the factors influencing dyspnea varied among the three MS types.
Background: Single-center studies indicated a high diagnostic accuracy of dynamic computed tomography perfusion (CTP) imaging in the diagnosis of coronary artery disease (CAD).
Objectives: This prospective multicenter study determined the diagnostic performance of combined coronary computed tomography angiography (CTA) and CTP for detecting hemodynamically significant CAD defined by invasive coronary angiography (ICA) with fractional flow reserve (FFR).
Methods: Seven centers enrolled 174 patients with suspected or known CAD who were clinically referred for ICA.
Aims: Isometric handgrip (IHG) training reduces the blood pressure in patients with hypertension. It is unclear how IHG exercise affects the haemodynamics and cardiovascular function through the muscle reflex in patients with heart failure (HF) with reduced (HFrEF) and preserved ejection fraction (HFpEF).
Methods And Results: Twenty patients (HFrEF: n = 10, HFpEF: n = 10) underwent left ventricular (LV) pressure-volume assessments using a conductance catheter and microtip manometer to evaluate haemodynamics, LV and arterial function, and LV-arterial coupling during 3 min of IHG at 30% of maximal voluntary contraction (MVC), followed by 3 min of post-exercise circulatory arrest (PECA).
Article Synopsis
- The study investigates the effects of diastolic interventricular septal flattening on clinical outcomes in patients with severe tricuspid regurgitation by analyzing data from 407 patients over a median follow-up of 200 days.
- Major findings indicated that the eccentricity index (EI) at end-diastole and left ventricular ejection fraction were key predictors of cardiovascular events, with an EI of 1.2 being a critical cutoff for poor hemodynamic status.
- Patients exhibiting a D-shaped left ventricle (EI ≥1.2) had significantly worse outcomes compared to those who did not, highlighting the importance of monitoring this condition in clinical practice.
Aims: This study investigated geometric differences in mitral valve apparatus between atrial functional mitral regurgitation (A-FMR) and functional mitral regurgitation (FMR) with left ventricular (LV) dysfunction in patients with atrial fibrillation (AF) using 3D transoesophageal echocardiography (TOE).
Methods And Results: In total, 135 moderate or greater FMR patients with persistent AF or atrial flutter underwent 3D TOE. Fifty-six patients had A-FMR, defined as preserved LV ejection fraction (LVEF) of ≥50% and normal LV wall motion.
Article Synopsis
- Moderate aortic stenosis (AS) can cause heart failure (HF) symptoms that aren't always related to the severity of the condition, making it difficult to pinpoint causes.
- A study analyzed 317 patients with moderate AS and found that 32% had HF symptoms, which were more common in those with higher systolic blood pressure (BP) and certain heart characteristics.
- The research determined that both systolic BP (with a significant odds ratio for each 10 mm Hg increase) and left atrial volume index were independently related to the presence of HF symptoms in these patients.
Myocardial extracellular volume (ECV) by cardiac magnetic resonance (CMR) in the acute phase of acute myocardial infarction (MI) more precisely predicts the functional recovery of infarct-related wall motion abnormalities and left ventricular (LV) remodeling than late gadolinium enhancement (LGE). The purpose of this study was to evaluate the prognostic importance of acute phase ECV in patients with AMI. We evaluated 61 consecutive AMI patients using 3.
View Article and Find Full Text PDFBackground: A new grading of tricuspid regurgitation (TR) beyond severe has been proposed. However, few studies assessing the validity of such a new grading scheme of TR have been conducted. Therefore, we evaluated associations of TR grades beyond severe with patient outcome and hemodynamics.
View Article and Find Full Text PDFPulmonary capillary hemangiomatosis is a rare form of pulmonary artery hypertension; to date, only few descriptions of myocardial pathology in pulmonary capillary hemangiomatosis have been reported in the literature. We report the case of a Japanese female patient who was diagnosed with pulmonary capillary hemangiomatosis combined with acute myocardial inflammation on performing autopsy. She was admitted to our hospital because of acute pneumonia and subsequently suddenly developed severe hypoxemia with breathing difficulty and died 13 days after admission.
View Article and Find Full Text PDFObjectives: This study sought to evaluate the potential of cardiac magnetic resonance T mapping to detect load-independent left ventricular (LV) chamber stiffness by histological confirmation.
Background: Accurate noninvasive diagnosis of LV diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF) remains challenging.
Methods: Nineteen HFpEF patients (14 female, 65 ± 16 years of age) without primary cardiomyopathy were prospectively enrolled.
The high prevalence of pulmonary hypertension (PH) in elderly patients is well known. However, much remains unknown about those population. We sought to find the clinical characteristics of echocardiographic PH and the prognostic factors in patients ≥90 years of age.
View Article and Find Full Text PDFBackground: Left ventricular (LV) diastolic dysfunction is the main cause of heart failure with preserved ejection fraction (HFpEF), and is characterized by LV stiffness and relaxation. Abnormal LV global longitudinal strain (GLS) is frequently observed l in HFpEF, and was shown to be useful in identifying HFpEF patients at high risk for a cardiovascular event. Cardiovascular magnetic resonance (CMR) feature tracking (CMR-FT) enables the reproducible and non-invasive assessment of global strain from cine CMR images.
View Article and Find Full Text PDFThe mechanisms of the diuretic effect of sodium-glucose cotransporter 2 (SGLT2) inhibitor and its predictors in heart failure (HF) patients with coexisting type 2 diabetes mellitus (T2DM) remain under investigation. A total of 40 hospitalized HF patients with T2DM (68 ± 13 years old, male gender 63%) were prospectively enrolled and received ipragliflozin at a dose of 50 mg once daily after breakfast for at least 4 consecutive days. They underwent first-morning blood and urine tests, and 24-h urine tests before and after short-term ipragliflozin therapy.
View Article and Find Full Text PDFObjectives: This study aimed to evaluate whether myocardial blood flow (MBF) quantified with dynamic computed tomography perfusion imaging (CTP) has an incremental prognostic value over coronary CT angiography (CTA) for major adverse cardiac events (MACEs) in patients with suspected coronary artery disease (CAD).
Background: The incremental prognostic value of CTP over CTA is unclear. The quantification of MBF with dynamic CTP may potentially enhance risk stratification.
An 82-year-old man with a permanent pacemaker (PM) implanted for sick sinus syndrome complained of palpitation due to paroxysmal atrial fibrillation and flutter. During extensive pulmonary vein isolation, the atrial lead was dislodged to the level of the tricuspid annulus. Radiofrequency energy delivery to the cavotricuspid isthmus reproducibly caused twitching of the PM pocket.
View Article and Find Full Text PDFPurpose: Regular physical activity (PA) is recommended for patients with heart failure (HF). However, the clinical and social characteristics of older HF patients with low-level PA and the impact of light-intensity PA on 6-mo postdischarge adverse cardiovascular events are still unclear.
Methods: Forty-one older patients who had been admitted because of decompensated HF (American College of Cardiology [ACC]/American Heart Association [AHA] HF classification stage C/D: 76 ± 5 y) were prospectively enrolled.
Aims: Unrecognized myocardial scar by late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) is strongly associated with cardiac event in patients with stable coronary artery disease. The purpose of this study was to evaluate the prognostic impact of unrecognized non-infarct-related LGE (non-IR-LGE) in patients with acute myocardial infarction (AMI).
Methods And Results: We studied 269 patients with a first clinical episode of AMI underwent cardiac MRI within 6 weeks after onset (209 men; age, 66 ± 12 years).