Publications by authors named "Omoregie Osazuwa"
Infection with Lassa virus (LASV) can cause Lassa fever, a haemorrhagic illness with an estimated fatality rate of 29.7%, but causes no or mild symptoms in many individuals. Here, to investigate whether human genetic variation underlies the heterogeneity of LASV infection, we carried out genome-wide association studies (GWAS) as well as seroprevalence surveys, human leukocyte antigen typing and high-throughput variant functional characterization assays.
View Article and Find Full Text PDFArticle Synopsis
- * Despite testing negative for the Lassa virus (LAV) in her blood, LAV was detected in her cerebrospinal fluid (CSF) through RT-PCR testing, leading to a diagnosis of acute LAV encephalitis.
- * After receiving supportive care and an 18-day ribavirin treatment, she fully recovered with no long-term neurological issues, and follow-up tests showed no presence of the virus in her CSF.
Background: Lassa fever is a viral haemorrhagic disease endemic to west Africa. No large-scale studies exist from Nigeria, where the Lassa virus (LASV) is most diverse. LASV diversity, coupled with host genetic and environmental factors, might cause differences in disease pathophysiology.
View Article and Find Full Text PDF