Publications by authors named "Omoregie O Osazuwa"
Infection with Lassa virus (LASV) can cause Lassa fever, a haemorrhagic illness with an estimated fatality rate of 29.7%, but causes no or mild symptoms in many individuals. Here, to investigate whether human genetic variation underlies the heterogeneity of LASV infection, we carried out genome-wide association studies (GWAS) as well as seroprevalence surveys, human leukocyte antigen typing and high-throughput variant functional characterization assays.
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- * Despite testing negative for the Lassa virus (LAV) in her blood, LAV was detected in her cerebrospinal fluid (CSF) through RT-PCR testing, leading to a diagnosis of acute LAV encephalitis.
- * After receiving supportive care and an 18-day ribavirin treatment, she fully recovered with no long-term neurological issues, and follow-up tests showed no presence of the virus in her CSF.